Blood Glucose Control System with Medicament Bolus Recommendation

1. An automated glucose control system configured to provide automatic delivery of glucose control therapy to a subject and receive information about manual glucose control therapy provided to the subject, the automated glucose control system comprising: a medicament delivery interface configured to operatively connect to a medicament pump configured to infuse medicament into the subject; a user interface controller configured to receive input signals corresponding to user interaction with a user interface; a memory configured to store specific computer-executable instructions and a therapy log; and a hardware processor in communication with the memory and configured to execute the specific computer-executable instructions to at least: generate an indication of an amount of a bolus of medicament via a control algorithm configured to control glucose level in the subject, wherein the bolus of medicament corresponds to a meal bolus of medicament or a correction bolus of medicament, and wherein the amount of the bolus of medicament is selected by the control algorithm based at least in part on preceding periods of glycemic control in the subject; generate a display of a manual bolus screen comprising a manual bolus control element and a bolus recommendation comprising the indication of the amount of the bolus of medicament generated by the control algorithm; receive, via user interaction with the manual bolus control element, an indication of an amount of a manual bolus of medicament; store, in the therapy log, the indication of the amount of the manual bolus of medicament supplied to the subject and an indication of a time when the manual bolus of medicament was supplied to the subject; model a diminishment of the medicament in the subject over time based at least in part on the manual bolus of medicament; and operate the control algorithm for automatic generation of an insulin dosing signal configured to operate the medicament pump to control glucose level in the subject based at least in part on a glucose level signal received from a glucose level sensor operatively connected to the subject and a time course of activity of the medicament in the subject due to a finite rate of utilization of the medicament, wherein operating the control algorithm for automatic generation of the insulin dosing signal comprises modifying administration of a bolus of insulin in response to a time interval between the time of the manual bolus and a time of the automatic generation of the insulin dosing signal being less than or equal to a threshold time interval.

2. An ambulatory medical device comprising the automated glucose control system of claim 1 and the medicament pump.

3. The ambulatory medical device of claim 2 , wherein the medicament pump comprises at least one of an insulin pump or a counter-regulatory agent pump.

4. The automated glucose control system of claim 1 , wherein the hardware processor is further configured to execute the specific computer-executable instructions to at least model an accumulation of the manual bolus of the medicament in the subject following subcutaneous infusion of the medicament.

5. The automated glucose control system of claim 1 , further comprising a wireless electronic communications interface configured to receive the indication of the amount of the manual bolus of medicament from an electronic device remote from the automated glucose control system.

6. The automated glucose control system of claim 1 , wherein receiving the indication of the amount of the manual bolus of medicament comprises detecting a gesture interaction made by a user.

7. The automated glucose control system of claim 6 , wherein detecting the gesture interaction made by the user comprises confirming that the gesture interaction matches a specified gesture interaction required for entry of the manual bolus of medicament.

8. The automated glucose control system of claim 1 , wherein receiving the indication of the amount of the manual bolus of medicament comprises receiving an estimate of a meal size or an estimate of a number of carbohydrates consumed by the subject.

9. The automated glucose control system of claim 1 , wherein receiving the indication of the amount of the manual bolus of medicament comprises receiving an estimate of an intensity of exercise engaged in by the subject.

10. The automated glucose control system of claim 1 , wherein the hardware processor is further configured to execute the specific computer-executable instructions to at least generate a dose control signal based at least in part on the indication of the amount of the manual bolus of medicament.

11. The automated glucose control system of claim 10 , wherein the hardware processor is further configured to execute the specific computer-executable instructions to at least provide the dose control signal to the medicament pump.

12. The automated glucose control system of claim 10 , wherein the manual bolus of medicament is infused through injection therapy or pump therapy.

13. The automated glucose control system of claim 10 , wherein modeling the diminishment of the medicament in the subject over time enables an estimate of a future effect of medicament previously infused into the subject.

14. The automated glucose control system of claim 1 , wherein the hardware processor is further configured to execute the specific computer-executable instructions to at least determine the time interval based at least in part on the therapy log.

15. The automated glucose control system of claim 1 , wherein modifying the administration of the bolus of insulin comprises omitting administration of the bolus of insulin or reducing the bolus of insulin administered.

16. The automated glucose control system of claim 1 , wherein the hardware processor is further configured to execute the specific computer-executable instructions to at least: determine an expected glucose level of the subject based at least in part on the manual bolus of medicament; and administer additional medicament in response to determining that a measured glucose level does not satisfy the expected glucose level.

17. The automated glucose control system of claim 1 , wherein the hardware processor is further configured to execute the specific computer-executable instructions to at least confirm delivery of the manual bolus of medicament based at least in part on the glucose level signal.

18. The automated glucose control system of claim 1 , wherein the hardware processor is further configured to execute the specific computer-executable instructions to at least modify the administration of the bolus of insulin based on the model of the diminishment of the medicament in the subject over time based at least in part on the manual bolus of medicament.

19. An automated glucose control system configured to provide automatic delivery of glucose control therapy to a subject and receive information about manual glucose control therapy provided to the subject, the automated glucose control system comprising: a glucose sensor interface operative to receive a glucose level signal from a sensor operative to determine a glucose level of the subject at periodic measurement intervals; a delivery device interface configured to transmit an insulin dose control signal to a medicament pump operative to deliver doses of insulin to the subject; a memory configured to store specific computer-executable instructions; and a hardware processor in communication with the memory and configured to execute the specific computer-executable instructions to at least: receive an indication of an amount of a manual bolus of insulin from a user interface; and automatically generate the insulin dose control signal based at least in part on the glucose level signal, an accumulation of insulin in the subject due to finite rate of utilization of the insulin, an input parameter corresponding to a weight of the subject, the indication of the amount of the manual bolus of insulin, and an indication of a time when the manual bolus of insulin was supplied to the subject, wherein automatically generating the insulin dose control signal further comprises modifying administration of a bolus of insulin in response to a time interval between the time when the bolus of insulin was supplied to the subject and a time of the automatic generation of the insulin dose control signal being less than or equal to a threshold time interval.

20. The automated glucose control system of claim 19 , wherein the input parameter comprises a measure of weight, a body mass value, or a body mass index value.

21. The automated glucose control system of claim 19 , wherein the insulin dose control signal is automatically adjusted based on the amount of the manual bolus of insulin.

22. The automated glucose control system of claim 19 , wherein the hardware processor is further configured to execute the specific computer-executable instructions to at least generate a glucagon dose control signal based at least in part on the indication of the amount of the manual bolus of insulin.

23. An automated glucose control system configured to provide automatic delivery of glucose control therapy to a subject and receive information about manual glucose control therapy provided to the subject, the automated glucose control system comprising: a medicament delivery interface configured to operatively connect to a medicament pump configured to infuse medicament into the subject; a user interface controller configured to receive input signals corresponding to user interaction with a user interface; a memory configured to store specific computer-executable instructions; and a hardware processor in communication with the memory and configured to execute the specific computer-executable instructions to at least: receive a meal announcement from a user responsive to the user interaction with the user interface, wherein the meal announcement comprises an indication of a size of a meal consumed or to be consumed by the subject; determine a meal bolus of insulin to administer to the subject based at least in part on the meal announcement, the meal bolus of insulin comprising an amount of insulin to administer to the subject to compensate for a change in glucose attributable to the meal; output for display an indication of the meal bolus of insulin; receive an indication of a requested modification to the meal bolus of insulin from the user; and operate a control algorithm for automatic generation of an insulin dosing signal configured to operate the medicament pump to control glucose level in the subject based at least in part on a glucose level of the subject and the modification to the meal bolus of insulin, wherein operating the control algorithm for automatic generation of the insulin dosing signal further comprises modifying administration of a bolus of insulin in response to a time interval between the time of the modification to the meal bolus and a time of the automatic generation of the insulin dosing signal being less than or equal to a threshold time interval.

24. The automated glucose control system of claim 23 , wherein the user is the subject or a caregiver of the subject.

25. The automated glucose control system of claim 23 , wherein the meal announcement is received via a wireless electronic communications interface configured to connect to a remote electronic device.