Method and Apparatus for Clinical Effects-Based Targeting of Neurostimulation

2. The system of claim 1, wherein the stimulation configuration circuitry is further configured to determine the stimulation configuration by minimizing a difference between the stimulation volume and the target volume.

3. The system of claim 2, wherein the stimulation configuration circuitry is further configured to determine the stimulation configuration by minimizing a Hamming distance between the stimulation volume and the target volume, a spatial distance between the stimulation volume and the target volume, or a distance between edge or contour points of the stimulation volume and the target volume.

4. The system of claim 1, comprising a user interface including a display screen, a user input device, and the stimulation control circuit, and wherein the volume definition circuitry is further configured to present a graphical representation of a volume of the one or more test volumes and the target volume in a volume panel on the display screen and to present a graphical representation of a stimulation configuration corresponding to the presented volume in a stimulation configuration panel on the display screen.

5. The system of claim 4, wherein the volume definition circuitry is further configured to present the graphical representation of the volume in at least a cross-sectional view at a user-selected cross-section received using the user input device or a perspective view at a user-selected perspective angle received using the user input device.

6. The system of claim 1, wherein the stimulation control circuit is configured to determine each electrode configuration of the one or more electrode configurations by specifying a selection of one or more electrodes from the plurality of electrodes and a fractionalization of electrical current flowing through the selected one or more electrodes.

7. The system of claim 1, wherein the stimulation configuration circuitry is further configured to generate a recommendation for a direction for determining the target volume using the one or more test volumes, the one or more clinical effects, and one or more threshold parameters and to determine the target volume using the recommendation.

10. The method of claim 9, wherein automatically generating the stimulation configuration comprises determining the stimulation configuration by minimizing a difference between the stimulation volume and the target volume.

11. The method of claim 10, wherein minimizing the difference between the stimulation volume and the target volume comprises minimizing a Hamming distance between the stimulation volume and the target volume.

12. The method of claim 10, wherein minimizing the difference between the stimulation volume and the target volume comprises minimizing a spatial distance between the stimulation volume and the target volume.

13. The method of claim 10, wherein minimizing the difference between the stimulation volume and the target volume comprises minimizing a distance between edge or contour points of the stimulation volume and the target volume.

15. The method of claim 14, further comprising presenting the graphical representation of the volume in at least a cross-sectional view at a user-selected cross-section received by the user interface or a perspective view at a user-selected perspective angle received by the user interface.

16. The method of claim 9, wherein automatically generating the stimulation configuration comprises determining, for each electrode configuration of the one or more electrode configurations, a selection of one or more electrodes from the plurality of electrodes and a fractionalization of electrical current flowing through the selected one or more electrodes.

17. The method of claim 9, wherein determining the one or more clinical effects comprises determining one or more therapeutic benefits and one or more side effects.

19. The non-transitory computer-readable storage medium of claim 18, wherein automatically generating the stimulation configuration comprises determining the stimulation configuration by minimizing a difference between the stimulation volume and the target volume.

20. The non-transitory computer-readable storage medium of claim 18, wherein automatically generating the stimulation configuration comprises determining, for each electrode configuration of the one or more electrode configurations, a selection of one or more electrodes from the plurality of electrodes and a fractionalization of electrical current flowing through the selected one or more electrodes.