Anaesthesia and Consciousness Depth Monitoring System

1. A biological signal monitoring apparatus for providing biological, neurological, physiological or cognitive state of a subject, comprising: one or more sensors configured to detect an input signal channel containing a noise signal and a biological input signal evoked in response to a stimulus, the one or more sensor attached to skin of the subject; a circuitry including a processor executing a computer program including instructions, which when executed by the processor, cause the processor to: automatically control a width of an aperture window of the biological input signal to determine noise characteristic of the noise signal; in response to a determination that the noise signal has the noise characteristic based on the controlled aperture window, extract the noise signal from the input signal channel and remove noise; adjust a phase and an amplitude of the extracted noise signal based on the noise characteristic by removing residual noise to generate an adjusted noise signal; combine the adjusted noise signal with the biological input signal to generate a combined biological signal; track the residual noise from the combined biological signal to continuously cancel a subsequent noise signal detected in the input signal channel based on the residual noise; non-linear dynamic transform the combined biological signal to generate a marker of the biological, neurological, physiological or cognitive state of the subject, wherein the processor is configured to delineate between non-linear dynamic transformed biological signal that are implicated in depth of hypnosis or depth of unconsciousness and the combined biological signal that are reflective of: wake-state, consciousness-state, or states associated with wake-state or consciousness-state and generate the marker based on the delineation; and generate signal quality indicators indicating quality of the combined biological signal after cancelling and adjusting the noise signal and a graphical representation of the marker; and in response to the cancelling and adjusting the noise signal, one or more first light emitting diodes electrically connected to the circuitry and configured to emit visible light representing the quality of the combined biological signal as assessment of the input signal channel; and a display configured to display the graphical representation and the signal quality indicators for a user feedback, wherein the biological signal monitoring apparatus includes: one or more second light emitting diodes configured to indicate a contact status between the one or more sensors and the subject's skin.

2. The biological signal monitoring apparatus of claim 1, wherein the display is configured to display a contact status indicator indicating the contact status of each sensor for the user feedback.

3. The biological signal monitoring apparatus of claim 1, wherein the instructions further cause the processor to: before the determination that the noise signal has the noise characteristic: determine a plurality of points of the input signal channel at which noise is the highest; sample and hold the plurality of points of the input signal channel to generate a timing reference signal; and synchronize the timing reference signal with the biological input signal to generate a synchronized signal.

4. The biological signal monitoring apparatus of claim 3, wherein the synchronized signal is generated by interleaving the biological input signal with the input signal channel at one or more portions between the plurality of points of the input signal channel at which noise is the highest.

5. The biological signal monitoring apparatus of claim 1, wherein the instructions further cause the processor to: based on the adjusted combined biological signal: in response to a determination that another noise signal has another noise characteristic, extract the another noise signal from the input signal channel; adjust the another noise signal extracted based on the another noise characteristic to generate another adjusted noise signal based on the residual noise; combine the another adjusted noise signal with the biological input signal to generate another combined biological signal; and track another residual noise from in the another combined biological signal.

6. The biological signal monitoring apparatus of claim 5, wherein the instructions further cause the processor to minimize the noise frequency of the biological input signal.

7. The biological signal monitoring apparatus of claim 5, wherein the instructions further cause the processor to maximize predetermined raw portions of the biological input signal.

8. The biological signal monitoring apparatus of claim 7, wherein the predetermined raw portions of the biological input signal are predetermined by a user of the biological signal monitoring apparatus.

9. The biological signal monitoring apparatus of claim 1, wherein the combined biological signal is non-linear dynamic transformed by quantitative measurement of disorder, an ability to predict future data based on previous data characteristics, a spectral entropy, a complexity analysis; and at least one of entropy delineating between underlying nonlinear neurological signals associated with deep hypnosis and signals reflecting wake or conscious periods.

10. The biological signal monitoring apparatus of claim 1, wherein the source of the noise signal is predetermined by a user of the biological signal monitoring apparatus.

11. The biological signal monitoring apparatus of claim 1, wherein the noise signal is cyclical.

12. The biological signal monitoring apparatus of claim 1, wherein the input signal channel is a channel at which a cyclical signal is generated.

13. The biological signal monitoring apparatus of claim 1, wherein the biological input signal is cyclical.

14. The biological signal monitoring apparatus of claim 1, wherein the source of the noise signal is one or more signals selected from the group consisting of: magnetic resonance imaging echo; equipment disturbance; mains noise; entropy; waveform morphology; electromyography signal intrusion; electrooculography signal intrusion; human body movement; and human body arousal.

15. The biological signal monitoring apparatus of claim 1, wherein the noise signal is extracted from: the frequency spectrum of the input signal channel; or the amplitude values of the input signal channel.

16. The biological signal monitoring apparatus of claim 1, wherein the noise signal is extracted from a phase-shifted version of the input signal channel.

17. A method of monitoring a biological signal using the biological signal monitoring apparatus of claim 1 for providing biological, neurological, physiological or cognitive state of a subject, comprising: detecting an input signal channel containing a noise signal and a biological input signal evoked in response to a stimulus, the one or more sensor attached to skin of the subject; automatically controlling a width of an aperture window of the biological input signal to determine noise characteristic of a noise signal; in response to a determination that the noise signal has the noise characteristic based on the controlled aperture window, extracting the noise signal from the input signal channel and removing noise; adjusting a phase and an amplitude of the extracted noise signal based on the noise characteristic by removing residual noise to generate an adjusted noise signal; combining the adjusted noise signal with a biological input signal to generate a combined biological signal; tracking the residual noise from the combined biological signal to continuously cancel a subsequent noise signal detected in the input signal channel based on the residual noise; non-linear dynamic transforming the combined biological signal to generate a marker of the biological, neurological, physiological or cognitive state of the subject, the non-linear dynamic transforming including: delineating between non-linear dynamic transformed biological signal that are implicated in depth of hypnosis or depth of unconsciousness and the combined biological signal that are reflective of: wake-state, consciousness-state, or states associated with wake-state or consciousness-state and generating the marker based on the delineation; generating signal quality indicators indicating quality of the combined biological signal after cancelling and adjusting the noise signal, a contact status indicator indicating a contact status of each sensor for the user feedback and a graphical representation of the marker; in response to the cancelling and adjusting the noise signal, controlling one or more first light to emit visible light representing the quality of the combined biological signal as assessment of the input signal channel and controlling one or more second light emitting diodes to indicate a contact status between the one or more sensors and the subject's skin; and displaying the graphical representation and the signal quality indicators for a user feedback.

18. A non-transitory computer-readable storage medium storing a computer program including instructions, which when executed by a processor of a biological signal monitoring apparatus for providing biological, neurological, physiological or cognitive state of a subject, cause the processor to: determine that an input signal channel detected by one or more sensors contains a noise signal, the one or more sensor attached to skin of the subject; automatically control a width of an aperture window of the biological input signal to determine noise characteristic of the noise signal; in response to a determination that the noise signal has a noise characteristic based on a controlled aperture window, extract the noise signal from the input signal channel and remove noise; adjust a phase and an amplitude of the extracted noise signal based on the noise characteristic by extracting residual noise to generate an adjusted noise signal; combine the adjusted noise signal with a biological input signal to generate a combined biological signal; track the residual noise from the combined biological signal to continuously cancel a subsequent noise signal in the input signal channel based on the residual noise; and non-linear dynamic transform the combined biological signal to generate a marker of the biological, neurological, physiological or cognitive state of the subject, wherein the processor is configured to delineate between non-linear dynamic transformed biological signal that are implicated in depth of hypnosis or depth of unconsciousness and the combined biological signal that are reflective of: wake-state, consciousness-state, or states associated with wake-state or consciousness-state and generate the marker based on the delineation; and generate signal quality indicators indicating quality of the combined biological signal after cancelling and adjusting the noise signal, a contact status indicator indicating a contact status of each sensor for the user feedback and a graphical representation of the marker so that the graphical representation and the signal quality indicators are displayed for a user feedback, one or more first light emitting diodes emit visible light corresponding to the quality of the combined biological signal, and one or more second light emitting diodes configured to indicate a contact status between the one or more sensors and the subject's skin.