Legal claims defining the scope of protection, as filed with the USPTO.
1. A method of correcting attenuation in a magnetic resonance (MR) scanner and a positron emission tomography (PET) unit, the method comprising: acquiring PET sinogram data of an object within a field of view of the PET unit; and producing an attenuation map based on a maximum likelihood expectation maximization (MLEM) of a parameterized model instance and the PET sinogram data.
2. The method of claim 1 , further comprising: acquiring MR data of an object within a field of view of the MR scanner; and producing a first attenuation map based on the acquired MR data.
3. The method of claim 2 , wherein the producing the attenuation map includes producing the first attenuation map and a second attenuation map.
4. The method of claim 3 , wherein the second attenuation map provides maximum likelihood of the PET sinogram data within a field of view of the PET unit including all parts not within the field of view of the MR scanner.
5. The method of claim 1 , wherein the producing the attenuation map includes, generating a model, parameterizing the model by model parameters, and creating the parameterized model instance based on the acquired PET sinogram data and the parameterized model.
6. The method of claim 5 , wherein the model is a statistical model.
7. The method of claim 6 , wherein the parameterizing the statistical model includes parameterizing the statistical model by deformation parameters, attenuation parameters and affine parameters.
8. The method of claim 6 , wherein the generating the statistical model includes performing principal component analysis of deformation fields and attenuation maps resulting from coregistrations of example data sets.
9. The method of claim 1 , wherein the producing the attenuation map includes, generating a model, and adapting the model to an initial attenuation map, the parameterized model instance being created based on the adapted model.
10. The method of claim 1 , wherein the PET unit is configured to acquire the PET sinogram data.
11. The method of claim 1 , wherein a computer connected to the MR scanner and the PET unit is configured to produce the attenuation map.
12. A non-transitory computer-readable medium, when run on a computer, configured to instruct the computer to perform the method of claim 1 .
13. A method of correcting attenuation in a magnetic resonance (MR) scanner and a positron emission tomography (PET) unit, the method comprising: acquiring PET sinogram data of an object within a field of view of the PET unit; acquiring MR data of the object within a field of view of the MR scanner; producing an attenuation map based on a maximum likelihood expectation maximization (MLEM) of a parameterized model instance and the acquired PET sinogram and MR data, the MLEM being constrained by model parameters of the parameterized model instance.
14. The method of claim 13 , wherein the producing the attenuation map includes producing a PET attenuation map.
15. The method of claim 14 , wherein the producing the PET attenuation map includes, generating a model, parameterizing the model by the model parameters, and creating the parameterized model instance based on the parameterized model.
16. The method of claim 15 , wherein the model is a statistical model.
17. The method of claim 16 , wherein the model parameters are the deformation parameters and the attenuation appearance parameters.
18. The method of claim 17 , wherein the model parameters further include affine parameters.
19. The method of claim 14 , further comprising: producing an MR attenuation map.
20. The method of claim 13 , wherein the producing the attenuation map includes, generating a model, and adapting the model to an initial attenuation map, the parameterized model instance being created based on the adapted model.
21. The method of claim 13 , wherein the PET unit is configured to acquire the PET sinogram data.
22. The method of claim 13 , wherein a computer connected to the MR scanner and the PET unit is configured to produce the attenuation map.
23. The method of claim 13 , wherein the MR scanner is configured to acquire the MR data.
24. A non-transitory computer-readable medium, when run on a computer, configured to instruct the computer to perform the method of claim 13 .
25. A device comprising: a positron emission tomography (PET) unit including a plurality of detection units and configured to acquire PET sinogram data of an object within a field of view of the PET unit; a magnetic resonance (MR) scanner configured to acquire MR data of the object within a field of view of the MR scanner; and a computer configured to produce an attenuation map based on a maximum likelihood expectation maximization (MLEM) of a parameterized model instance and the acquired PET sinogram and MR data, the MLEM being constrained by model parameters of the parameterized model instance.
Unknown
October 30, 2012
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