Matching Patient Images and Images of an Anatomical Atlas

1. A data processing method for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, the method being performed by a computer and comprising: acquiring atlas data, the acquiring the atlas data comprising sub-steps of: acquiring atlas spatial information, the atlas spatial information comprising spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, the acquiring the patient data comprising sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, based on the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the determination rule describes an assignment between the plurality of atlas elements and the plurality of representation data sets by describing a surjective assignment between the atlas elements and representation classes, wherein the respective representation classes respectively represent subsets of the plurality of representation data sets, and wherein for each of the respective representation classes, there is a unique set of characteristic bijective assignments between individual representation data sets of the subsets and individual parameter sets.

2. The data processing method according to claim 1 , wherein determining the atlas image set comprises: determining the representation data sets for the corresponding elements, wherein for each atlas image to be determined, one of the representation data sets is determined for each of the corresponding elements in accordance with the determination rule, wherein the determination rule comprises an assignment rule for assigning a respective representation data set to a respective corresponding element in accordance with the parameter set associated with the patient image to which the atlas image which includes the corresponding element is to be matched; and, determining the atlas image set comprising one or more images which are respectively associated with one of the parameter sets, by respectively using the determined representation data sets to determine the representations of the corresponding elements.

3. The data processing method according to claim 1 , further comprising: using image values of patient elements in combination with determining the matching transformation in order to determine the representation of one or more of the corresponding elements in the one or more atlas images.

4. The data processing method according to claim 1 , wherein: the determining the matching transformation, which matches one of the atlas images and one of the patient images associated with one of the parameter sets to each other, comprises determining the matching transformation based on information on the matching transformation between another of the atlas images and another of the patient images associated with another of the associated parameter sets.

5. The data processing method according to claim 1 , wherein: the matching transformation deforms a part of the geometry of the general anatomical structure in order to match the atlas images to the patient images; and the determining the matching transformation comprises taking into account information on the influence on matching quality of a deformation of at least one of the atlas images associated with at least one of the parameter sets in order to determine the deformation of at least another of the atlas images which is associated with at least another of the parameter sets and includes corresponding elements which are identical to the corresponding elements included in said at least one of the atlas images.

6. The data processing method according to claim 1 , wherein determining the matching transformation comprises: assuming that the spatial information described by the atlas images is identical; and using information on the spatial correlation between the spatial information described by the patient images in order to determine deformations described by the matching transformation which is applied in order to match the atlas images and patient images to each other.

7. The data processing method according to claim 1 , wherein the matching transformation comprises a set of coupled transformations referred to as matching sub-transformations, wherein the respective matching sub-transformations respectively match the atlas images associated with one of the associated parameter sets and the patient image which is associated with the same respective associated parameter set to each other, and the matching sub-transformations are coupled in that they each influence the determination of the other.

8. The data processing method according to claim 1 , wherein the representation data sets describe types of information on representation comprising at least one of: image values for the anatomical elements; ranges of image values for the anatomical elements; the relationship between image values of different anatomical elements; the relationship between image values for one or more of the anatomical elements represented in images associated with different parameter sets; maximum image values for the anatomical elements; minimum image values for the anatomical elements; average image values for the anatomical elements; standard deviations of the average image values and structures of modulations of the image values for the anatomical elements; and, characteristics of transitions between representations of different anatomical elements.

9. The data processing method according to claim 1 : wherein the atlas data comprises spatial flexibility information which describes a flexibility of the position of atlas elements within the general anatomical structure; and determining the matching transformation based on the spatial flexibility information.

10. The data processing method according to claim 1 , further comprising: acquiring correspondence part data which describe the corresponding elements, the acquiring the correspondence part data comprising acquiring coarse atlas spatial information which describes the spatial information on the general anatomical structure in less detail than the atlas spatial information used to determine the atlas image set, the acquiring the correspondence data comprising applying a rigid matching transformation for matching the at least one patient image to a part of the general anatomical structure described by the coarse atlas spatial information, in order to determine the part of the general anatomical structure which allows a predetermined optimum of the matching result to be achieved, in particular a predetermined optimum of a measure of similarity, when determining the matching transformation, and wherein the corresponding elements are determined on the basis of the atlas elements included in the determined part.

11. The data processing method according to claim 1 , wherein the atlas spatial information comprises a description of a plurality of different states of the general anatomical structure which are respectively described by different sets of spatial information, wherein the plurality of different states correspond in particular to a time-dependent set of spatial information which in particular comprises a description of a time-dependent vital movement of at least part of the general anatomical structure, wherein acquiring the correspondence part data comprises determining a time state of the plurality of different states, which allows a predetermined optimum of the matching result to be achieved, in particular a predetermined optimum of a measure of similarity, when determining the matching transformation.

12. The data processing method according to claim 1 , further comprising performing one or more of: applying the matching transformation to the atlas image set in order to determine matched atlas images; and/or applying the matching transformation to the patient image set in order to determine matched patient images.

13. The data processing method according to claim 1 : wherein the general anatomical structure comprises pathological changes, wherein the patient image is associated with one of a plurality of different parameters referred to as patho parameters, wherein the patho parameters specify the pathological changes in accordance with a classification, wherein the atlas spatial information contains a plurality of spatial information on the general anatomical structure for a plurality of patho parameters, wherein the element representation information describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined for a plurality of patho parameters, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets and in accordance with the patho parameter associated with the set of patient images; and: wherein the acquiring patient data comprises sub-steps of: acquiring the patho parameter associated with the patient image, wherein the acquired one or more parameter sets are respectively associated with the same patho parameter; wherein the determining the set of atlas images comprises: determining, on the basis of the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure associated with the patho parameter by using the spatial information on the general anatomical structure associated with the patho parameter and particular representation data sets associated with the patho parameter which are determined by applying the determination rule in accordance with the patho parameter and one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image, wherein at least a part of the general anatomical structure comprises pathological changes in accordance with the patho parameter and corresponds to at least a part of the anatomical structure represented on the patient image; and wherein the determining the matching transformation comprises determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set and the same patho parameter to each other.

14. The data processing method of claim 13 , wherein the atlas data contain spatial meta information on the pathological changes, and further comprising matching by the determined matching transformation the spatial meta information to the patient image.

15. A program for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, the program being embodied on a non-transitory computer readable medium, the program, when running on a computer or when loaded onto a computer, causing the computer to perform steps comprising: acquiring atlas data, the acquiring the atlas data comprising sub-steps of: acquiring atlas spatial information, the atlas spatial information comprising spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, the acquiring the patient data comprising sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, based on the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the determination rule describes an assignment between the plurality of atlas elements and the plurality of representation data sets by describing a surjective assignment between the atlas elements and representation classes, wherein the respective representation classes respectively represent subsets of the plurality of representation data sets, and wherein for each of the respective representation classes, there is a unique set of characteristic bijective assignments between individual representation data sets of the subsets and individual parameter sets.

16. A non-transitory program storage medium on which the program of claim 15 is stored.

17. A computer for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, a program, being running on the computer or being loaded into the memory of the computer and causing the computer to perform steps comprising: acquiring atlas data, the acquiring the atlas data comprising sub-steps of: acquiring atlas spatial information, the atlas spatial information comprising spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, the acquiring the patient data comprising sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, based on the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the determination rule describes an assignment between the plurality of atlas elements and the plurality of representation data sets by describing a surjective assignment between the atlas elements and representation classes, wherein the respective representation classes respectively represent subsets of the plurality of representation data sets, and wherein for each of the respective representation classes, there is a unique set of characteristic bijective assignments between individual representation data sets of the subsets and individual parameter sets.

18. A medical image processing system, comprising: one or more analytical devices for generating patient images of a patient; and the computer of claim 17 configured to determine the matching transformation and apply the matching transformation in order to match the generated patient images and determined atlas images.

19. A data processing method for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, the method comprising the following steps performed by a computer of: acquiring atlas data, comprising the sub-steps of: acquiring atlas spatial information which contains spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, comprising the sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, on the basis of the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the matching transformation is designed to deform a part of the geometry of the general anatomical structure in order to match the atlas images to the patient images, and wherein determining the matching transformation involves taking into account information on the influence on matching quality of a deformation of at least one of the atlas images associated with at least one of the parameter sets in order to determine the deformation of at least another of the atlas images which is associated with at least another of the parameter sets and includes corresponding elements which are identical to the corresponding elements included in said at least one of the atlas images.

20. A program for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, the program being embodied on a non-transitory computer readable medium, the program, when running on a computer or when loaded onto a computer, causing the computer to perform the following steps: acquiring atlas data, comprising the sub-steps of: acquiring atlas spatial information which contains spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, comprising the sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, on the basis of the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the matching transformation is designed to deform a part of the geometry of the general anatomical structure in order to match the atlas images to the patient images, and wherein determining the matching transformation involves taking into account information on the influence on matching quality of a deformation of at least one of the atlas images associated with at least one of the parameter sets in order to determine the deformation of at least another of the atlas images which is associated with at least another of the parameter sets and includes corresponding elements which are identical to the corresponding elements included in said at least one of the atlas images.

21. A non-transitory program storage medium on which the program of claim 20 is stored.

22. A computer for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, a program being running on the computer or being loaded into the memory of the computer and causing the computer to perform the following steps: acquiring atlas data, comprising the sub-steps of: acquiring atlas spatial information which contains spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, comprising the sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, on the basis of the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the matching transformation is designed to deform a part of the geometry of the general anatomical structure in order to match the atlas images to the patient images, and wherein determining the matching transformation involves taking into account information on the influence on matching quality of a deformation of at least one of the atlas images associated with at least one of the parameter sets in order to determine the deformation of at least another of the atlas images which is associated with at least another of the parameter sets and includes corresponding elements which are identical to the corresponding elements included in said at least one of the atlas images.

23. A medical image processing system, comprising: analytical devices for generating patient images of a patient; and the computer of claim 22 which is designed to determine the matching transformation and apply the matching transformation in order to match the generated patient images and determined atlas images.

24. A data processing method for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, the method comprising the following steps performed by a computer of: acquiring atlas data, comprising the sub-steps of: acquiring atlas spatial information which contains spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, comprising the sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, on the basis of the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the atlas data also comprise spatial flexibility information which describes a flexibility of the position of atlas elements within the general anatomical structure, and wherein the matching transformation is determined on the basis of the spatial flexibility information.

25. A program for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, the program being embodied on a non-transitory computer readable medium, the program, when running on a computer or when loaded onto a computer, causing the computer to perform the following steps: acquiring atlas data, comprising the sub-steps of: acquiring atlas spatial information which contains spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, comprising the sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, on the basis of the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the atlas data also comprise spatial flexibility information which describes a flexibility of the position of atlas elements within the general anatomical structure, and wherein the matching transformation is determined on the basis of the spatial flexibility information.

26. A non-transitory program storage medium on which the program of claim 25 is stored.

27. A computer for determining a matching transformation for matching a set of one or more images of an anatomical body structure of an associated patient, referred to as a patient image set, and a set of one or more images of a general anatomical structure, referred to as an atlas image set, wherein the general anatomical structure comprises a plurality of anatomical elements referred to as atlas elements, and each patient image is associated with one of a plurality of different parameter sets, wherein the parameter sets comprise one or more parameters which obtain when the patient images are generated, and the parameters influence representations of anatomical elements in the patient images, a program being running on the computer or being loaded into the memory of the computer and causing the computer to perform the following steps: acquiring atlas data, comprising the sub-steps of: acquiring atlas spatial information which contains spatial information on the general anatomical structure; and, acquiring element representation information which describes a plurality of representation data sets which contain information on representations of the plurality of atlas elements in the atlas images to be determined, wherein the element representation information describes a determination rule for determining respective representation data sets for respective atlas elements in accordance with different respective parameter sets; acquiring patient data, comprising the sub-steps of: acquiring the patient image set; and, acquiring one or more of the plurality of parameter sets which are respectively associated with the one or more images of the patient image set; determining, on the basis of the atlas data and the patient data, the set of atlas images which respectively represent at least a part of the general anatomical structure by using the spatial information on the general anatomical structure and particular representation data sets which are determined by applying the determination rule in accordance with the one or more associated parameter sets and particular atlas elements acquired and referred to as corresponding elements, which are to be matched to corresponding anatomical elements represented in the patient image; and, determining the matching transformation which matches the atlas image set and the patient image set, by matching images associated with the same parameter set to each other, wherein the atlas data also comprise spatial flexibility information which describes a flexibility of the position of atlas elements within the general anatomical structure, and wherein the matching transformation is determined on the basis of the spatial flexibility information.

28. A medical image processing system, comprising: one or more analytical devices for generating patient images of a patient; and the computer of claim 27 configured to determine the matching transformation and apply the matching transformation in order to match the generated patient images and determined atlas images.