Minimizing Uncertainty Envelopes in Trajectories of Evolving Ensemble Members

1. A method, in a data processing system comprising at least one processor and at least one memory, the at least one memory comprising instructions executed by the at least one processor to cause the at least one processor to implement a simulation system for minimizing uncertainty envelopes in trajectories of evolving ensemble members, the method comprising: receiving, by the simulation system from a user, a set of defining parameters for selecting member objects of an ensemble, wherein each member object within the ensemble of member objects comprises a patient given a test drug in a clinical trial, wherein the set of defining parameters comprises gender, age, and weight; identifying, by the simulation system, the ensemble of member objects satisfying the defining parameters; generating, by a predictor executing within the simulation system, a trajectory forecast of each member object of the ensemble based on an initial state-space and a model for predicting trajectories of the member objects to generate a plurality of trajectory forecasts, wherein each of the plurality of trajectory forecasts has an individual uncertainty envelope and wherein the ensemble has an ensemble uncertainty envelope, wherein the initial state-space comprises a set of biological parameters monitored; applying, by a clustering system executing within the simulation system, a classification algorithm on the plurality of trajectory forecasts to identify at least one group of member objects having similar trajectory forecasts; generating, by an envelope calculator executing within the simulation system, a reduced ensemble of member objects including the identified group of member objects; performing at least one targeted correction to the reduced ensemble of member objects, wherein the at least one targeted correction comprises an adjustment to treatment that is expected to cause the reduced ensemble to behave similarly; reconfiguring, by the simulation system, the state-space and the model for predicting trajectories for the reduced ensemble of member objects based on the at least one targeted correction; and generating, by the predictor executing within the simulation system, an updated trajectory forecast of each member object of the reduced ensemble based on the reconfigured state-space and the reconfigured model for predicting trajectories of the member objects.

2. The method of claim 1 , wherein generating the updated trajectory forecast comprises: measuring current states and parameter values for the reduced ensemble based on the reconfigured state-space; and generating the updated trajectory forecast of each member object of the reduced ensemble based on the current states and parameter values.

3. The method of claim 1 , wherein each ensemble member has measurable properties that serve as state variables to define its location in the state-space at any given time and intrinsic parameters that determine changes in location from one time to another in the state-space.

4. The method of claim 3 , wherein the model predicts the future location of each ensemble member given its current measurable properties and its intrinsic parameters.

5. The method of claim 1 , further comprising: calculating a predicted uncertainty envelope of trajectories of the reduced ensemble.

6. The method of claim 5 , wherein calculating the predicted uncertainty envelope of trajectories comprises applying a minimax estimate function to the reduced ensemble.

7. The method of claim 1 , wherein applying the classification algorithm on the plurality of trajectory forecasts comprises identifying a plurality of sub-groups of member objects having similar trajectory forecasts.

8. The method of claim 7 , further comprising applying a minimax estimate function to each sub-group of member objects to predict a respective uncertainty envelope of trajectories.

9. The method of claim 1 , wherein the classification algorithm comprises a k-means clustering algorithm.

10. A computer program product comprising a computer readable storage medium having a computer readable program stored therein, wherein the computer readable program, when executed on a computing device, causes the computing device to implement a simulation system for minimizing uncertainty envelopes in trajectories of evolving ensemble members, the computer readable program causing the computing device to: receive, by the simulation system from a user, a set of defining parameters for selecting member objects of an ensemble, wherein each member object within the ensemble of member objects comprises a patient given a test drug in a clinical trial, wherein the set of defining parameters comprises gender, age, and weight; identify, by the simulation system, the ensemble of member objects satisfying the defining parameters; generate, by a predictor executing within the simulation system, a trajectory forecast of each member object of the ensemble based on an initial state-space and a model for predicting trajectories of the member objects to generate a plurality of trajectory forecasts, wherein each of the plurality of trajectory forecasts has an individual uncertainty envelope and wherein the ensemble has an ensemble uncertainty envelope, wherein the initial state-space comprises a set of biological parameters monitored; apply, by a clustering system executing within the simulation system, a classification algorithm on the plurality of trajectory forecasts to identify at least one group of member objects having similar trajectory forecasts; generate, by an envelope calculator executing within the simulation system, a reduced ensemble of member objects including the identified group of member objects; perform at least one targeted correction on the reduced ensemble of member objects, wherein the at least one targeted correction comprises an adjustment to treatment that is expected to cause the reduced ensemble to behave similarly; reconfigure, by the simulation system, the state-space and the model for predicting trajectories for the reduced ensemble of member objects based on at least one targeted correction performed on the reduced ensemble of member objects; and generate, by the predictor executing within the simulation system, an updated trajectory forecast of each member object of the reduced ensemble based on the reconfigured state-space and the reconfigured model for predicting trajectories of the member objects.

11. The computer program product of claim 10 , wherein generating the updated trajectory forecast comprises: measuring current states and parameter values for the reduced ensemble based on the reconfigured state-space; and generating the updated trajectory forecast of each member object of the reduced ensemble based on the current states and parameter values.

12. The computer program product of claim 10 , wherein the computer readable program further causes the computing device to: calculate a predicted uncertainty envelope of trajectories of the reduced ensemble.

13. The computer program product of claim 12 , wherein calculating the predicted uncertainty envelope of trajectories comprises applying a minimax estimate function to the reduced ensemble.

14. The computer program product of claim 10 , wherein the classification algorithm comprises a k-means clustering algorithm.

15. An apparatus comprising: at least one processor; and a memory coupled to the at least one processor, wherein the memory comprises instructions which, when executed by the at least one processor, cause the at least one processor to implement a simulation system for minimizing uncertainty envelopes in trajectories of evolving ensemble members, the instructions causing the at least one processor to: receive, by the simulation system from a user, a set of defining parameters for selecting member objects of an ensemble, wherein each member object within the ensemble of member objects comprises a patient given a test drug in a clinical trial, wherein the set of defining parameters comprises gender, age, and weight; identify, by the simulation system, the ensemble of member objects satisfying the defining parameters; generate, by a predictor executing within the simulation system, a trajectory forecast of each member object of an ensemble based on an initial state-space and a model for predicting trajectories of the member objects to generate a plurality of trajectory forecasts, wherein each of the plurality of trajectory forecasts has an individual uncertainty envelope and wherein the ensemble has an ensemble uncertainty envelope, wherein the initial state-space comprises a set of biological parameters monitored; apply, by a clustering system executing within the simulation system, a classification algorithm on the plurality of trajectory forecasts to identify at least one group of member objects having similar trajectory forecasts; generate, by an envelope calculator executing within the simulation system, a reduced ensemble of member objects including the identified group of member objects; reconfigure, by the simulation system, the state-space and the model for predicting trajectories for the reduced ensemble of member objects based on at least one targeted correction performed on the reduced ensemble of member objects, wherein the at least one targeted correction comprises an adjustment to treatment that is expected to cause the reduced ensemble to behave similarly; and generate, by the predictor executing within the simulation system, an updated trajectory forecast of each member object of the reduced ensemble based on the reconfigured state-space and the reconfigured model for predicting trajectories of the member objects.

16. The apparatus of claim 15 , wherein generating the updated trajectory forecast comprises: measuring current states and parameter values for the reduced ensemble based on the reconfigured state-space; and generating the updated trajectory forecast of each member object of the reduced ensemble based on the current states and parameter values.

17. The apparatus of claim 15 , wherein the instructions further cause the processor to: calculate a predicted uncertainty envelope of trajectories of the reduced ensemble.

18. The apparatus of claim 17 , wherein calculating the predicted uncertainty envelope of trajectories comprises applying a minimax estimate function to the reduced ensemble.

19. The apparatus of claim 15 , wherein the classification algorithm comprises a k-means clustering algorithm.