The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. A series of signal evolutions are acquired from the volume in the subject to form MRF data. The MRF data is then compared to simulated MRF signal to determine parameters associated with phosphate metabolites and the chemical exchange rates between these metabolites. These parameters and exchange rates can be used in diagnosing a metabolic disorder in a subject.
Legal claims defining the scope of protection, as filed with the USPTO.
1. A method for performing phosphorous spectroscopic magnetic resonance fingerprinting (MRF) comprising: performing a pulse sequence using a series of varied sequence blocks to simultaneously produce different signal evolutions from different resonant species in a volume in a subject, wherein at least one member of the series of varied sequence blocks differs from at least one other member of the series of varied sequence blocks in at least N sequence block parameters, where N is an integer greater than one and wherein the different resonant species include one or more metabolites; acquiring MRF data as the series of different signal evolutions from different resonant species in the volume in the subject; determining parameters associated with phosphate metabolites and chemical exchange rates between these metabolites by comparing the MRF data to a simulated MRF signal; and identifying metabolic alterations in the subject based on the determined parameters.
2. The method of claim 1 wherein the metabolite parameter includes quantifying the concentration (M 0 ) of at least one of the one or more metabolites.
3. The method of claim 1 wherein the metabolite parameter includes quantifying a rate constant for at least one of the one or more metabolites.
4. The method of claim 3 wherein the rate constant includes a forward ATP rate constant (k f ATP ).
5. The method of claim 1 wherein performing a pulse sequence using a series of varied sequence blocks includes using a constant repetition time (TR).
6. The method of claim 1 wherein using a series of varied sequence blocks includes using linearly ramped flip angles.
7. The method of claim 1 wherein the simulated MRF signal includes signals correlated to at least one known metabolite parameter for the one or more metabolites.
8. The method of claim 1 wherein the one or more metabolites include phosphorus-31 ( 31 P).
9. The method of claim 8 wherein the one or more metabolites is selected from the group consisting of inorganic phosphate, phosphocreatine (PCr), adenosine triphosphate (ATP), adenosine diphosphate, and creatine.
10. The method of claim 1 wherein the pulse sequence is a hyperbolic secant inversion pulse.
11. A method for performing phosphorous spectroscopic magnetic resonance fingerprinting (MRF) comprising: performing a pulse sequence using a series of varied sequence blocks to a volume in a subject, the volume containing one or more metabolites; acquiring a series of signal evolutions from the volume in the subject to form MRF data; determining parameters associated with phosphate metabolites and chemical exchange rates between these metabolites by comparing the MRF data to simulated MRF signal; and identifying metabolic alterations in the subject based on the determined parameters; wherein the simulated MRF signal includes signals correlated to at least one known metabolite parameter for the one or more metabolites; and wherein the at least one known metabolite parameter includes chemical shift data and a range of longitudinal relaxation times (T 1 ).
12. A method for performing phosphorous spectroscopic magnetic resonance fingerprinting (MRF) comprising: performing a pulse sequence using a series of varied sequence blocks to a volume in a subject, the volume containing one or more metabolites; acquiring a series of signal evolutions from the volume in the subject to form MRF data; determining parameters associated with phosphate metabolites and chemical exchange rates between these metabolites by comparing the MRF data to simulated MRF signal; identifying metabolic alterations in the subject based on the determined parameters; and characterizing the one or more metabolites by assigning the MRF data associated with the one or more metabolites to at least one spectral bin.
13. A method for performing phosphorous spectroscopic magnetic resonance fingerprinting (MRF) comprising: performing a pulse sequence using a series of varied sequence blocks to a volume in a subject, the volume containing one or more metabolites; acquiring a series of signal evolutions from the volume in the subject to form MRF data; determining parameters associated with phosphate metabolites and chemical exchange rates between these metabolites by comparing the MRF data to simulated MRF signal; identifying metabolic alterations in the subject based on the determined parameters; and wherein comparing the MRF data to the simulated MRF signal includes taking a dot product between the at least one known metabolite parameter in the simulated MRF signal and the MRF data in the at least one spectral bin.
14. A method for performing phosphorous spectroscopic magnetic resonance fingerprinting (MRF) comprising: performing a pulse sequence using a series of varied sequence blocks to a volume in a subject, the volume containing one or more metabolites; acquiring a series of signal evolutions from the volume in the subject to form MRF data; determining parameters associated with phosphate metabolites and chemical exchange rates between these metabolites by comparing the MRF data to simulated MRF signal; and identifying metabolic alterations in the subject based on the determined parameters; wherein identifying the metabolic alternations includes generating a matched fingerprint; and wherein the matched fingerprint is the highest dot product between the acquired MRF data and simulated MRF signal with predefined metabolite parameters.
15. The method of claim 14 wherein the at least one metabolite parameter is T 1 .
17. A method for performing spectroscopic magnetic resonance fingerprinting (MRF) comprising: performing a pulse sequence using a series of varied sequence blocks to simultaneously produce different signal evolutions from different resonant species in a volume in an object, the volume containing one or more metabolites; acquiring the simultaneously produced different signal evolutions from different resonant species to form MRF data, wherein the signal evolutions are positioned in a pass-band; characterizing the one or more metabolites by comparing one of the signal evolutions from the MRF data to a simulated MRF signal, wherein comparing including performing signal template matching to select a set of values from the simulated MRF signal that correspond to the signal evolution from the MRF data; and determining at least one metabolite parameter based at least in part on the selected set of values from the simulated MRF signal.
18. The method of claim 17 wherein determining the at least one metabolite parameter for the one or more metabolites includes generating a matched fingerprint.
19. A method for performing spectroscopic magnetic resonance fingerprinting (MRF) comprising: performing a pulse sequence using a series of varied sequence blocks to a volume in an object, the volume containing one or more metabolites; acquiring a series of signal evolutions from the volume in the object to form MRF data, wherein the signal evolutions are positioned in a pass-band; characterizing the one more metabolites by comparing the MRF data to simulated MRF signal; determining at least one metabolite parameter; and wherein positioning the signal evolution within the pass-band includes varying the carrier frequency and TR.
20. A system comprising: a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject; a magnetic gradient system including a plurality of magnetic gradient coils configured to apply at least one magnetic gradient field to the polarizing magnetic field; a radio frequency (RF) system configured to apply an RF field to the subject and to receive magnetic resonance signals from the subject using a coil array; a computer system programmed to: control the magnetic gradient system and the RF system to perform a pulse sequence using a series of varied sequence blocks to elicit different signal evolutions from different resonant species in a volume in a subject containing one or more metabolites, wherein at least one member of the series of varied sequence blocks differs from at least one other member of the series of varied sequence blocks in at least N sequence block parameters, where N is an integer greater than one; and acquire a series of the signal evolutions from the volume to form MRF data, wherein the signal evolutions are positioned in a pass-band; characterize the one or more metabolites by comparing one of the signal evolutions from the MRF data to a simulated MRF signal wherein comparing including performing signal template matching to select a set of values from the simulated MRF signal that correspond to the signal evolution from the MRF data; and generate a report indicating at least the one or more metabolites.
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May 8, 2017
December 3, 2019
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