A computer system for generating a diagnostic tool by applying artificial intelligence to an instrument for diagnosis of a disorder, such as autism. For autism, the instrument can be a caregiver-directed set of questions designed for an autism classification tool or an observation of the subject in a video, video conference, or in person and associated set of questions about behavior that are designed for use in a separate autism classification tool. The computer system can have one or more processors and memory to store one or more computer programs having instructions for generating a highly statistically accurate set of diagnostic items selected from the instrument, which are tested against a first test using a technique using artificial intelligence and a second test against an independent source. Also, a computer implemented method and a non-transitory computer-readable storage medium are disclosed.
Legal claims defining the scope of protection, as filed with the USPTO.
1. A computer system for diagnosing a behavioral disorder, a developmental delay, or a neurological impairment of a subject with a diagnostic tool comprising a classifier and a set of diagnostic questions, the computer system comprising: a processor; and a non-transitory computer readable medium that stores instructions that when executed by the processor causes the processor to: display the set of diagnostic questions; receive responses to the set of diagnostic questions; provide the responses as an input to the classifier, wherein the classifier is trained with data from a plurality of individuals having the behavioral disorder, the developmental delay, or the neurological impairment, and wherein the classifier has an accuracy of at least 90%; evaluate the responses with the classifier; and generate an output indicating whether there is an indication that the subject has the behavioral disorder, the developmental delay, or the neurological impairment.
2. The computer system of claim 1 , wherein the instructions further cause the processor to score the subject based on the responses and generate a final score of the subject indicative of a likelihood of a presence or an absence of the behavioral disorder, the developmental delay, or the neurological impairment in said subject.
3. The computer system of claim 2 , wherein the final score comprises a magnitude, and wherein the magnitude of the final score is indicative of one or more of a severity of the behavioral disorder, the developmental delay, or the neurological impairment or a confidence in the output.
4. The computer system of claim 1 , wherein the instructions further cause the processor to transform the responses into discrete numerical vectors, and wherein the responses are provided as the input into the classifier by providing the discrete numeral vectors as the input into the classifier.
5. The computer system of claim 1 , wherein the set of diagnostic questions are displayed on a website or an application of a personal computing device and the responses are received through the website or the application of the personal computing device.
6. The computer system of claim 1 , wherein the set of diagnostic questions comprises a subset of diagnostic questions of the Autism Diagnostic Interview-Revised, wherein the Autism Diagnostic Interview-Revised consists of 153 diagnostic questions, and wherein the subset of diagnostic questions of the diagnostic tool consists of 7 diagnostic questions.
7. The computer system of claim 6 , wherein a time for administering the Autism Diagnostic Interview-Revised is 2.5 hours, and wherein a time for administering the diagnostic tool is less than an hour.
8. The computer system of claim 6 , wherein subjects of the 7 diagnostic questions of the diagnostic tool are comprehension of simple language, reciprocal conversation, imaginative play, imaginative play with peers, direct gaze, group play with peers, and age when abnormality first evident.
9. The computer system of claim 1 , wherein the set of diagnostic questions comprises a subset of diagnostic questions of the Autism Diagnostic Observation Schedule-Generic, wherein the Autism Diagnostic Observation Schedule-Generic consists of four modules, wherein the first of the four modules consists of 29 diagnostic questions, and wherein the subset of diagnostic questions of the diagnostic tool consists of 8 diagnostic questions from the first module.
10. The computer system of claim 9 , wherein a time for administering the Autism Diagnostic Observation Schedule-Generic is 2 to 4 hours, and wherein a time for administering the diagnostic tool is less than an hour.
11. The computer system of claim 9 , wherein subjects of the 8 diagnostic questions of the diagnostic tool are frequency of vocalization directed to others, unusual eye contact, responsive social smile, shared enjoyment in interaction, showing, spontaneous initiation of joint attention, functional play with objects, and imagination/creativity.
12. The computer system of claim 1 , wherein the instructions further cause the processor to: train an analyst to review a video of the subject; and score the video using the diagnostic tool.
13. The computer system of claim 1 , wherein the instructions further cause the processor to generate a report, wherein the report comprises a suggested clinical action.
14. The computer system of claim 13 , wherein the report further comprises at least one of the following: a link to a video of the subject; a list of facilities or clinicians, wherein the facilities or clinicians are capable of performing the suggested clinical action; and a map depicting locations of the facilities or clinicians capable of performing the suggested clinical action.
15. The computer system of claim 1 , wherein the instructions further cause the processor to evaluate the subject with a diagnostic instrument for diagnosis of the behavioral disorder, the developmental delay, or the neurological impairment if the subject demonstrates a need for further evaluation.
16. The computer system of claim 1 , wherein the instructions further cause the processor to treat the subject for the behavioral disorder, the developmental delay, or the neurological impairment.
17. A non-transitory computer-readable storage medium including instructions for diagnosing a behavioral disorder, a developmental delay, or a neurological impairment of a subject with a diagnostic tool comprising a classifier and a set of diagnostic questions, said instructions comprising: displaying the set of diagnostic questions; receiving responses to the set of diagnostic questions; providing the responses as an input to the classifier, wherein the classifier is trained with data from a plurality of individuals having the behavioral disorder, the developmental delay, or the neurological impairment, and wherein the classifier has an accuracy of at least 90%; evaluating the responses with the classifier; and generating an output indicating whether there is an indication that the subject has the behavioral disorder, the developmental delay, or the neurological impairment.
18. The non-transitory computer-readable storage medium of claim 17 , further comprising instructions for scoring the subject based on the responses and generating a final score of the subject indicative of a likelihood of a presence or an absence of the behavioral disorder, the developmental delay, or the neurological impairment in said subject.
19. The non-transitory computer-readable storage medium of claim 18 , wherein the final score comprises a magnitude, and wherein the magnitude of the final score is indicative of one or more of a severity of the behavioral disorder, the developmental delay, or the neurological impairment or a confidence in the output.
20. The non-transitory computer-readable storage medium of claim 17 , further comprising instructions for transforming the responses into discrete numerical vectors, and wherein providing the responses as the input into the classifier comprises providing the discrete numeral vectors as the input into the classifier.
21. The non-transitory computer-readable storage medium of claim 17 , further comprising instructions for displaying the set of diagnostic questions on a website or an application of a personal computing device and receiving the responses through the website or the application of the personal computing device.
22. The non-transitory computer-readable storage medium of claim 17 , wherein the set of diagnostic questions comprises a subset of diagnostic questions of the Autism Diagnostic Interview-Revised, wherein the Autism Diagnostic Interview-Revised consists of 153 diagnostic questions, and wherein the subset of diagnostic questions of the diagnostic tool consists of 7 diagnostic questions.
23. The non-transitory computer-readable storage medium of claim 22 , wherein a time for administering the Autism Diagnostic Interview-Revised is 2.5 hours, and wherein a time for administering the diagnostic tool is less than an hour.
24. The non-transitory computer-readable storage medium of claim 22 , wherein subjects of the 7 diagnostic questions of the diagnostic tool are comprehension of simple language, reciprocal conversation, imaginative play, imaginative play with peers, direct gaze, group play with peers, and age when abnormality first evident.
25. The non-transitory computer-readable storage medium of claim 17 , wherein the set of diagnostic questions comprises a subset of diagnostic questions of the Autism Diagnostic Observation Schedule-Generic, wherein the Autism Diagnostic Observation Schedule-Generic consists of four modules, wherein the first of the four modules consists of 29 diagnostic questions, and wherein the subset of diagnostic questions of the diagnostic tool consists of 8 diagnostic questions from the first module.
26. The non-transitory computer-readable storage medium of claim 25 , wherein a time for administering the Autism Diagnostic Observation Schedule-Generic is 2 to 4 hours, and wherein a time for administering the diagnostic tool is less than an hour.
27. The non-transitory computer-readable storage medium of claim 25 , wherein subjects of the 8 diagnostic questions of the diagnostic tool are frequency of vocalization directed to others, unusual eye contact, responsive social smile, shared enjoyment in interaction, showing, spontaneous initiation of joint attention, functional play with objects, and imagination/creativity.
28. The non-transitory computer-readable storage medium of claim 17 , wherein the one or more computer programs further comprise instructions for: training an analyst to review a video of the subject; and scoring the video using the diagnostic tool.
29. The non-transitory computer-readable storage medium of claim 17 , further comprising instructions for generating a report, wherein the report comprises a suggested clinical action.
30. The non-transitory computer-readable storage medium of claim 29 , wherein the report further comprises at least one of the following: a link to a video of the subject; a list of facilities or clinicians, wherein the facilities or clinicians are capable of performing the suggested clinical action; and a map depicting locations of the facilities or clinicians capable of performing the suggested clinical action.
31. The non-transitory computer-readable storage medium of claim 17 , further comprising instructions for evaluating the subject with a diagnostic instrument for diagnosis of the behavioral disorder, the developmental delay, or the neurological impairment if the subject demonstrates a need for further evaluation.
32. The non-transitory computer-readable storage medium of claim 17 , further comprising instructions for treating the subject for the behavioral disorder, the developmental delay, or the neurological impairment.
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August 3, 2016
June 23, 2020
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