The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.
Legal claims defining the scope of protection, as filed with the USPTO.
1. A method comprising: at a computing system comprising one or more processors and memory storing one or more programs for execution by the one or more processors: obtaining a plurality of images of an in vivo tissue located at a region of interest on a subject, each respective image in the plurality of images resolved at a particular spectral band of radiation in a plurality of spectral bands, wherein corresponding pixels in each image in the plurality of images are co-registered into an array of sets of co-registered pixels; deconvolving the co-registered pixels in each set of co-registered pixels in the plurality of images into a coefficient that represents an amount of oxyhemoglobin (x) in the in vivo tissue located at the region of interest and a coefficient that represents an amount of deoxyhemoglobin (y) in the in vivo tissue located at the region of interest; generating, based on the plurality of images, a two-dimensional pseudo-color image of the in vivo tissue, wherein the two-dimensional pseudo-color image includes a representation of a concentration of oxyhemoglobin in the in vivo tissue based on one of a color scale and a color saturation scale, and a representation of a concentration of deoxyhemoglobin in the in vivo tissue based on the other of the color scale and the color saturation scale; and displaying texts of the coefficient for oxyhemoglobin (x) and the coefficient for deoxyhemoglobin (y) for a single set of co-registered pixels in the plurality of images or a sub-array of sets of co-registered pixels in the plurality of images with the two-dimensional pseudo-color image on a single display, wherein the text of the coefficient for oxyhemoglobin (x) reflects the concentration of oxyhemoglobin represented in the pseudo-color image based on the one of the color scale and the color saturation scale and the text of the coefficient for deoxyhemoglobin (y) represents the concentration of deoxyhemoglobin as represented in the pseudo-color image based on the other of the color scale and the color saturation scale, thereby displaying a patterning of oxyHb and deoxyHb concentrations for the region of interest.
2. The method of claim 1 , wherein the computing system comprises a portable multispectral or hyperspectral medical imaging system and a second computing system located at a remote location.
3. The method of claim 2 , wherein the method further comprises transferring the plurality of images from the portable multispectral or hyperspectral medical imaging system to the second computing system via a communications link.
4. The method of claim 3 , wherein the second computing system located at the remote location performs any of: co-registering corresponding pixels in each image in the plurality of images; deriving the coefficient for oxyhemoglobin and the coefficient for deoxyhemoglobin from each set of co-registered pixels in the plurality of images; and generating, based on the plurality of images, the two-dimensional pseudo-color image of the in vivo tissue.
5. The method of claim 1 , wherein each respective spectral band in the plurality of spectral bands has a bandwidth of less than 20 nm.
6. The method of claim 1 , wherein each respective spectral band in the plurality of spectral bands is adjacent to another, forming a continuous set of spectral bands.
7. The method of claim 1 , wherein at least one respective spectral band in the plurality of spectral bands is in the visible spectrum.
8. The method of claim 1 , wherein at least one respective spectral band in the plurality of spectral bands is in the near-infrared spectrum.
9. The method of claim 7 , wherein at least one respective spectral band in the plurality of spectral bands is in the near-infrared spectrum.
10. The method of claim 1 , further comprising displaying a text of a tissue oxygen saturation value (x/(x+y)) from the single set or the sub-array of sets of co-registered pixels in the plurality of images with the texts of the coefficients for oxyhemoglobin and deoxyhemoglobin.
11. The method of claim 1 , wherein the computing system further comprises a video display, wherein the text of the coefficient for oxyhemoglobin, the text of the coefficient for deoxyhemoglobin, and the two-dimensional pseudo-color image are displayed on the video display.
12. The method of claim 1 , wherein the computing system further comprises an image projector, wherein the text of the coefficient for oxyhemoglobin (x), the text of the coefficient for deoxyhemoglobin (y), and the two-dimensional pseudo-color image are projected onto the region of interest on the subject.
13. The method of claim 1 wherein the displaying the texts of the coefficient for oxyhemoglobin (x) and the coefficient for deoxyhemoglobin (y) comprises displaying a text of a sum of the coefficients for oxyhemoglobin and deoxyhemoglobin (x+y) and a text of a difference of the coefficients for oxyhemoglobin and deoxyhemoglobin (x−y).
14. The method of claim 1 , wherein the sub-array of sets of co-registered pixels displays an area of tissue that is at risk of ulceration or unlikely to heal.
15. The method of claim 1 , wherein the sub-array of sets of co-registered pixels displays an area of tissue that is likely to heal.
16. The method of claim 1 , wherein the sub-array of sets of co-registered pixels are defined by the user.
Cooperative Patent Classification codes for this invention. Click any code to explore related patents in that topic.
December 23, 2013
September 22, 2020
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