Some embodiments of the methods provided herein relate to sample analysis and particle characterization methods for large, multi-parameter data sets. Frequency difference gating compares at least two different data sets to identify regions in a multivariate space where a frequency of events from a first data set is different than a frequency of events from the second data set according to a defined threshold.
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2. The computer-implemented method of claim 1, wherein the first and second data sets comprise multi-parameter cell sample data.
3. The computer-implemented method of claim 1, wherein the at least one threshold includes an upper threshold identifying one or more regions classified as having a greater frequency of events from the first data set than the second data set.
4. The computer-implemented method of claim 1, wherein the at least one threshold includes a lower threshold identifying one or more regions having a greater frequency of events from the second data set than the first data set.
5. The computer-implemented method of claim 1, wherein the at least one threshold includes mid-range boundaries identifying one or more regions having a similar frequency of events as between the first data set and the second data set.
9. The system of claim 7, wherein the at least one threshold comprises a plurality of thresholds.
10. The system of claim 7, wherein displaying the visualization comprises displaying the regions with color coding indicating relative differences in event frequency between the first and second data sets, based at least in part on the frequency difference gate.
12. The system of claim 7, wherein the first sample comprises a control sample.
13. The system of claim 12, wherein the control sample corresponds to healthy matter.
14. The system of claim 12, wherein the control sample corresponds to cancerous matter.
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May 23, 2018
February 7, 2023
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