Patentable/Patents/US-12235197
US-12235197

Automatic processing device for liquid samples

PublishedFebruary 25, 2025
Assigneenot available in USPTO data we have
Inventorsnot available in USPTO data we have
Technical Abstract

An automatic processing device for liquid samples includes a sample region, a control module, an image identification device and a centrifuge. The sample region is configured to accommodate a plurality of centrifuge tubes. The control module includes a mechanical module. The mechanical module is configured to unscrew or tighten upper caps of the centrifuge tubes, and is configured to draw liquid from the centrifuge tubes or discharge liquid to the centrifuge tubes. The image identification device is coupled to the control module. The centrifuge is coupled to the control module. The centrifuge is configured to accommodate the centrifuge tubes and perform centrifugal treatment.

Patent Claims
19 claims

Legal claims defining the scope of protection, as filed with the USPTO.

1

1. An automatic processing device for liquid samples, comprising: a sample region, configured to accommodate a plurality of centrifuge tubes; a mechanical module comprising: a liquid drawing/dishing machine configured to draw liquid from the centrifuge tubes or discharge liquid to the centrifuge tubes, wherein the liquid drawing/discharging machine comprises: a roller, the roller having a first end and a second end opposite to each other, and a plurality of grooves spirally along the longitudinal axis of the roller; and a plurality of micropipettes operatively coupled to the plurality of grooves, wherein rotating the roller causes the micropipettes to move laterally in respect to the direction of the grooves; and a centrifuge configured to accommodate the centrifuge tubes and perform a centrifugal treatment.

2

2. The automatic processing device of claim 1, wherein the sample region is further configured to accommodate a plurality of blood collection tubes, and the automatic processing device further comprises: an image identification device configured to identify a sample label of each of the blood collection tubes and/or identify a height of a blood volume in each of the blood collection tubes, and/or configured to capture and identify images of the centrifuge tubes before the centrifugal treatment and/or after the centrifugal treatment.

3

3. The automatic processing device of claim 1, wherein the mechanical module further comprises an uncapping/capping machine.

4

4. The automatic processing device of claim 3, wherein the centrifuge tubes at least comprise a first group of the centrifuge tubes and a second group of the centrifuge tubes, and a size of each of the first group of the centrifuge tubes is larger than that of each of the second group of the centrifuge tubes, and the uncapping/capping machine comprises: a plurality of clamping portions, each of the clamping portions having a first clamping portion and a second clamping portion, and the second clamping portion located over the first clamping portion, and the first clamping portion corresponding to an upper cap of one of the first group of the centrifuge tubes, and the second clamping portion corresponding to an upper cap of one of the second group of the centrifuge tubes.

5

5. The automatic processing device of claim 1, wherein each of the grooves has a first end and a second end; wherein a first spacing between the first ends of a pair of adjacent grooves is smaller than a second spacing between the second ends of the grooves; wherein the grooves are divided into a first group of the grooves and a second group of the grooves, the first group of the grooves are proximal to the first end of the roller, and the first ends of the second group of the grooves are proximal to the second end of the roller.

6

6. An automatic processing device for liquid samples, comprising: a sample region, configured to accommodate a plurality of centrifuge tubes; a control module, comprising a mechanical module, wherein the mechanical module comprises: a liquid drawing/discharging machine configured to draw liquid from the centrifuge tubes or discharge liquid to the centrifuge tubes, wherein the liquid drawing/discharging machine comprises; a roller, the roller having a first end and a second end opposite to each other, and a plurality of grooves spirally along the longitudinal axis of the roller; and a plurality of micropipettes operatively coupled to the plurality of grooves, wherein rotating the roller causes the micropipettes to move laterally in respect to the direction of the grooves; an image identification device coupled to the control module; and a centrifuge coupled to the control module, wherein the centrifuge is configured to accommodate the centrifuge tubes and perform a centrifugal treatment.

7

7. The automatic processing device of claim 6, wherein the sample region is further configured to accommodate a plurality of blood collection tubes, and the image identification device is configured to identify a sample label of each of the blood collection tubes and/or identify a height of a blood volume in each of the blood collection tubes, wherein when in at least one of the blood collection tubes the height of the blood volume does not reach a set value, the mechanical module is further configured to add liquid to the at least one of the blood collection tubes that the height of the blood volume does not reach the set value to allow a height of the blood volume in the at least one of the blood collection tubes after the liquid is added to reach the set value.

8

8. The automatic processing device of claim 6, wherein the image identification device is configured to identify a certain layer of a sample in each of the centrifuge tubes, and the mechanical module is further configured to draw the layer from each of the centrifuge tubes.

9

9. The automatic processing device of claim 6, wherein the image identification device is configured to capture and identify images of the centrifuge tubes before the centrifugal treatment and/or after the centrifugal treatment.

10

10. The automatic processing device of claim 6, wherein the sample region comprises an uncapping/capping region and a liquid drawing/discharging region adjacent to the uncapping/capping region, and the device further comprises a carrier configured to carry the centrifuge tubes and move between the uncapping/capping region and the liquid drawing/discharging region.

11

11. The automatic processing device of claim 6, wherein the centrifuge tubes at least comprise a first group of the centrifuge tubes and a second group of the centrifuge tubes, and a size of each of the first group of the centrifuge tubes is larger than that of each of the second group of the centrifuge tubes, and the mechanical module further comprises: an uncapping/capping machine configured to simultaneously unscrew or tighten upper caps of the first group of the centrifuge tubes and configured to simultaneously unscrew or tighten upper caps of the second group of the centrifuge tubes.

12

12. The automatic processing device of claim 11, wherein the uncapping/capping machine comprises: a plurality of clamping portions, each of the clamping portions having a first clamping portion and a second clamping portion, and the second clamping portion located over the first clamping portion, and the first clamping portion corresponding to an upper cap of one of the first group of the centrifuge tubes, and the second clamping portion corresponding to an upper cap of one of the second group of the centrifuge tubes.

13

13. The automatic processing device of claim 11, wherein the sample region is further configured to accommodate a group of liquid sample tubes, and the uncapping/capping machine is further configured to pull up upper caps of the group of the liquid sample tubes.

14

14. The automatic processing device of claim 13, wherein the uncapping/capping machine comprises: a plurality of clamping portions, each of the clamping portions having a first clamping portion, a second clamping portion and a third clamping portion, and the second clamping portion located over the first clamping portion, and the third clamping portion located over the second clamping portion, and the first clamping portion corresponding to an upper cap of one of the first group of the centrifuge tubes, and the second clamping portion corresponding to an upper cap of one of the second group of the centrifuge tubes, and the third clamping portion corresponding to an upper cap of one of the liquid sample tubes.

15

15. The automatic processing device of claim 14, wherein a width of a third space defined by the third clamping portion is smaller than a width of a second space defined by the second clamping portion, and the width of the second space defined by the second clamping portion is smaller than a width of a first space defined by the first clamping portion.

16

16. The automatic processing device of claim 6, wherein the centrifuge tubes at least comprise a first group of the centrifuge tubes and a second group of the centrifuge tubes, and a size of each of the first group of the centrifuge tubes is larger than that of each of the second group of the centrifuge tubes, and the liquid drawing/discharging machine is configured to simultaneously draw liquid from or simultaneously add liquid to the first group of the centrifuge tubes, and configured to simultaneously draw liquid from or simultaneously add liquid to the second group of the centrifuge tubes.

17

17. The automatic processing device of claim 6, wherein each of the grooves has a first end and a second end; wherein a first spacing between the first ends of a pair of adjacent grooves is smaller than a second spacing between the second ends of the grooves; wherein the grooves are divided into a first group of the grooves and a second group of the grooves, the first group of the grooves are proximal to the first end of the roller, and the first ends of the second group of the grooves are proximal to the second end of the roller.

18

18. The automatic processing device of claim 6, wherein the device is configured to automatically separate peripheral blood mononuclear cells from a blood sample of a biological body.

19

19. The automatic processing device of claim 6, wherein the device is configured to automatically separate circulating tumor cells from a blood sample of a biological body.

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Patent Metadata

Filing Date

April 21, 2021

Publication Date

February 25, 2025

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Cite as: Patentable. “Automatic processing device for liquid samples” (US-12235197). https://patentable.app/patents/US-12235197

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