Provided herein is a method of detecting adrenomyeloneuropathy (AMN) in a human male subject, said method comprising determining the level of MFGE8, C1qa, Trem2, Gas6 or any combination thereof, in a biological sample obtained from the spine of the subject, wherein said level or levels are increased compared to a reference level or levels, thereby detecting AMN in the subject. Also provided is a method of treating AMN in a human male subject, said method comprising administering an anti-MFGE8 antibody to the subject.
Legal claims defining the scope of protection, as filed with the USPTO.
1. A method, comprising: providing a biological sample from a spine of a human male subject diagnosed with X-linked adrenoleukodystrophy (X-ALD), and detecting a level of milk fat globule-EGF factor 8 (MFGE8), complement C1q A chain (C1qa), triggering receptor expressed on myeloid cells 2 (Trem2), or growth arrest specific 6 (Gas6), in the sample.
2. The method of claim 1, wherein the biological sample is a biopsy of spinal tissue or spinal fluid.
3. The method of claim 1, comprising detecting a level of two or more of MFGE8, C1qa, Trem2, and Gas6.
4. The method of claim 1, comprising detecting a level of three or more of MFGE8, C1qa, Trem2, and Gas6.
5. The method of claim 1, comprising detecting a level of all four of MFGE8, C1qa, Trem2, and Gas6.
6. The method of claim 1, further comprising detecting one or both of tumor necrosis factor (TNF) alpha and interleukin 1 beta.
7. The method of claim 3, further comprising detecting one or both of tumor necrosis factor (TNF) alpha and interleukin 1 beta.
8. The method of claim 4, further comprising detecting one or both of tumor necrosis factor (TNF) alpha and interleukin 1 beta.
9. The method of claim 5, further comprising detecting one or both of tumor necrosis factor (TNF) alpha and interleukin 1 beta.
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October 1, 2018
April 15, 2025
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