Calibration of blood glucose measurement system based on Raman spectroscopy

1. A non-transitory computer readable medium containing program instructions executed by a processor, the program instructions when executed by the processor configured to: cause a light source to irradiate light to a subject such that the light is output at a predetermined output for a predetermined duration; receive, from a light receiver, electrical signals representative of a Raman spectrum of the light that is reflected and scattered from the subject, and wavelength components of which are separated by using a monochrome part; and determine an intensity and an exposure duration for the light to be irradiated by the light source to subsequently measure the blood glucose level of the subject, based on a peak corresponding to a specific Raman shift of the Raman spectrum acquired via the light receiver for the predetermined duration.

2. The non-transitory computer readable medium of claim 1, wherein the processor is configured to reduce noise in the Raman spectrum based on Savitzky-Golay filtering, and to remove a background by a polynomial fitting.

3. The non-transitory computer readable medium of claim 2, wherein an order of the polynomial fitting is selected to be suitable for removing the background and is determined based on intensities of four wavelengths, which includes a first wavelength, a wavelength at a point of two quarters, a wavelength at a point of three quarters, and a last wavelength.

4. The non-transitory computer readable medium of claim 1, wherein the peak corresponding to a specific Raman shift is at 1450 cm−1.

5. The non-transitory computer readable medium of claim 1, wherein, in response to an intensity of the peak corresponding to a specific Raman shift not reaching a predetermined threshold intensity level even with a predetermined maximum output and a predetermined maximum duration of the light source, the processor is configured to cause an error message to be transmitted.

6. The non-transitory computer readable medium of claim 1, wherein, in response to a ratio of intensities of general Raman signal peaks and a ratio of intensities of signal peaks of the Raman spectrum are different by a predetermined threshold or more, the processor is configured to determine that there is a contact error with the subject and to cause an error message to be transmitted.