Electron Beam Generation Apparatus and Electron Beam Generation Method

One aspect of the present invention relates to an electron beam generation apparatus and an electron beam generation method.

As electron beam generation apparatuses, there are known apparatuses that generate an electron beam by propagating pulsed laser light in a supersonic gas flow. For example, in an electron beam generation apparatus described in Non Patent Literature 1 below, a supersonic gas flow is generated under a vacuum atmosphere by a supersonic nozzle, and a shock wave is formed by inserting a knife edge (razor blade) into the generated supersonic gas flow. Then, an electron beam is generated by radiating and propagating pulsed laser light to pass through a shock wave in the supersonic gas flow.

Non Patent Literature 1: A. Buck et al. “Shock-Front Injector for High-Quality Laser-Plasma Acceleration,” PHYSICAL REVIEW LETTERS, American Physical Society, PRL 110, 185006 (2013), 3 May, 2013

The above-described electron beam generation apparatus has a concern that stability of the electron beam is low, and for example, a probability of generation of the electron beam is low.

In this regard, an object of one aspect of the present invention is to provide an electron beam generation apparatus and an electron beam generation method capable of enhancing stability of an electron beam.

(1) An electron beam generation device according to one aspect of the present invention is an electron beam generation apparatus configured to generate an electron beam by propagating pulsed laser light in a supersonic gas flow, the electron beam generation apparatus including a supersonic nozzle configured to generate the supersonic gas flow flowing along a first direction under a vacuum atmosphere, a knife edge configured to be inserted into the supersonic gas flow from one side in a second direction intersecting the first direction and form a shock wave in the supersonic gas flow, and a radiation unit configured to radiate the pulsed laser light into the supersonic gas flow and propagate the pulsed laser light to pass through the shock wave in the supersonic gas flow, in which the supersonic nozzle includes a convergence portion having a downstream end forming a throat and an upstream end having a flow channel cross-sectional area larger than a cross-sectional area of the throat, and a flow straightening chamber configured to be smoothly connected to the upstream end of the convergence portion and extend by a predetermined length.

(2) In the electron beam generation apparatus according to (1), the convergence portion and the flow straightening chamber may extend along the first direction, and the predetermined length may be 20 mm or longer. In this case, the flow straightening chamber of the supersonic nozzle enables, for example, the generation of a turbulent flow in the supersonic gas flow generated by the supersonic nozzle to be reliably curbed and enables the stability of the gas density distribution to be reliably enhanced. (3) In the electron beam generation apparatus of the present invention according to (1) or (2), the supersonic nozzle may include a flow straightening member configured to be provided inside the flow straightening chamber and have a plurality of fine holes formed in a flowing direction of the flow straightening chamber. In this case, a flow rectification of the flow straightening member enables, for example, the generation of a turbulent flow in the supersonic gas flow generated by the supersonic nozzle to be further curbed and enables the stability of the gas density distribution to be further enhanced. (4) In the electron beam generation apparatus according to (3), the convergence portion and the flow straightening chamber may extend along the first direction, and the predetermined length may be 10 mm or longer. In this case, the flow straightening chamber of the supersonic nozzle enables, for example, the generation of a turbulent flow in the supersonic gas flow generated by the supersonic nozzle to be reliably curbed and enables the stability of the gas density distribution to be reliably enhanced. (5) In the electron beam generation apparatus according to (3) or (4), the flow straightening member may be disposed inside the flow straightening chamber at a distance of 5 mm or longer from an upstream end or a downstream end of the flow straightening chamber. In this case, the flow rectification of the flow straightening member can be reliably exhibited. (6) In the electron beam generation apparatus according to any one of (1) to (5), at least a tip portion of the knife edge may be inclined toward the supersonic nozzle with respect to a direction perpendicular to the first direction. At least the tip portion of the knife edge is inclined toward the supersonic nozzle with respect to the direction perpendicular to the first direction, thereby enabling the shock wave linearly extending from the tip of the knife edge to be formed in the supersonic gas flow. In this case, a generation position of the electron beam in the supersonic gas flow can be stabilized, and the stability of the electron beam can be enhanced. (7) In the electron beam generation apparatus according to any one of (1) to (6), the supersonic nozzle may be configured to be dividable such that the flow straightening chamber is divided. In this case, the flow straightening chamber can be easily formed. (8) In the electron beam generation apparatus according to any one of (1) to (7), the knife edge may be configured to be able to adjust a length by which the knife edge is inserted into the supersonic gas flow. A change in the length by which the knife edge is inserted into the supersonic gas flow enables a magnitude and a position of a peak in the gas density distribution to be changed. For example, this enables a length of an acceleration region (a region where the gas density distribution is maintained within the certain range) on the other side in the second direction with respect to the peak in the gas density distribution to be adjusted as desired. Since the generated electron beam can be accelerated in the acceleration region, acceleration energy of the electron beam can be adjusted as desired. (9) In the electron beam generation apparatus according to any one of (1) to (8), the knife edge may be configured to be able to adjust an insertion angle being an angle between an extending direction of the knife edge and the second direction in a state where the knife edge is inserted into the supersonic gas flow. A change in the insertion angle of the knife edge enables the inclination of the shock wave formed in the supersonic gas flow to be changed. This enables parameters (a charge amount, a probability of generation, and the like) of the electron beam which is to be generated to be adjusted as desired. (10) In the electron beam generation apparatus according to any one of (1) to (9), the knife edge may cause a gas density distribution of the supersonic gas flow in the second direction to become a distribution that rises steeply, falls steeply, and then is maintained within a certain range from one side toward the other side in the second direction. In this case, the insertion of the knife edge into the supersonic gas flow from the one side in the second direction enables a gas density distribution suitable for generating the electron beam to be formed. (11) In the electron beam generation apparatus according to (10), the pulsed laser light radiated from the radiation unit may cause plasma wave crushing to occur, and the electron beam may be generated by the plasma wave crushing in a region where the gas density distribution of the supersonic gas flow in the second direction falls steeply, and the generated electron beam may be accelerated in an acceleration region where the gas density distribution of the supersonic gas flow in the second direction is maintained within the certain range. As described above, in the electron beam generation apparatus, the electron beam can be generated using the plasma wave crushing. In this case, the generated electron beam can be accelerated using a region where the gas density distribution is maintained within the certain range. (12) An electron beam generation method according to one aspect of the present invention is an electron beam generation method for generating an electron beam by propagating pulsed laser light in a supersonic gas flow, the electron beam generation method including a first step of generating the supersonic gas flow flowing along a first direction under a vacuum atmosphere by a supersonic nozzle, a second step of inserting a knife edge into the supersonic gas flow from one side in a second direction intersecting the first direction and forming a shock wave in the supersonic gas flow, and a third step of radiating the pulsed laser light into the supersonic gas flow by a radiation unit, propagating the pulsed laser light to pass through the shock wave in the supersonic gas flow, and generating the electron beam, in which the supersonic nozzle includes a convergence portion having a downstream end forming a throat and an upstream end having a flow channel cross-sectional area larger than a cross-sectional area of the throat, and a flow straightening chamber configured to be smoothly connected to the upstream end of the convergence portion and extend by a predetermined length. In the first step, a gas is caused to flow by a predetermined length in the flow straightening chamber, and then the gas converges while being caused to flow in the convergence portion. In the electron beam generation apparatus according to the one aspect of the present invention, the supersonic gas flow is formed under the vacuum atmosphere by the supersonic nozzle, the knife edge is inserted into the formed supersonic gas flow, and the shock wave is formed in the supersonic gas flow. When the pulsed laser light is radiated and propagated in the supersonic gas flow, the pulsed laser light passes through the shock wave, thereby causing the electron beam having directionality to the other side in the second direction to be generated. Here, as a result of close studies, the present inventors have found that the stability of the electron beam is affected by the stability of a gas density distribution of the supersonic gas flow (hereinafter, also simply referred to as a “gas density distribution”). In this respect, in the one aspect of the present invention, since the supersonic nozzle has the flow straightening chamber, for example, generation of a turbulent flow (uncertainty in turbulent motion) in the supersonic gas flow generated by the supersonic nozzle can be curbed, and the stability of the gas density distribution can be enhanced. This enables the stability of the electron beam to be enhanced.

In the electron beam generation method according to the one aspect of the present invention, in the first step of generating the supersonic gas flow flowing along the first direction under the vacuum atmosphere by the supersonic nozzle, the gas is caused to flow by the predetermined length in the flow straightening chamber, and then the gas converges while being caused to flow in the convergence portion. This causes, for example, the generation of a turbulent flow (uncertainty in turbulent motion) in the generated supersonic gas flow to be curbed, enables the stability of the gas density distribution to be enhanced, and enables the stability of the electron beam to be enhanced.

According to one aspect of the present invention, it is possible to provide an electron beam generation apparatus and an electron beam generation method capable of enhancing stability of an electron beam.

Hereinafter, embodiments will be described with reference to the drawings. In the following description, the same or corresponding elements are denoted by the same reference numerals, and redundant descriptions thereof are omitted. An X direction, a Y direction, and a Z direction are set for convenience based on an illustrated state.

1 FIG. 1 As illustrated in, an electron beam generation apparatusis an apparatus that generates an electron beam E for being radiated to a target subject. The target subject is not particularly limited, and examples thereof include a prodrug in a patient's body. In this case, the electron beam E acts as a trigger for changing the prodrug in the patient's body into an active substance. The prodrug is not particularly limited, and examples thereof include a prodrug that passes through the blood-brain barrier (a mechanism that restricts transit of a substance from blood to brain tissue).

1 1 1 2 3 4 5 The electron beam E generated by the electron beam generation apparatusmay have an energy higher than 1 MeV, an energy higher than 10 MeV, or an energy higher than 200 MeV. In a case where the target subject is a patient, the electron beam E may have an energy higher than 10 MeV. The electron beam generation apparatusaccording to this embodiment generates the electron beam E by propagating pulsed laser light L in a supersonic gas flow G. The electron beam generation apparatusincludes a vacuum vessel, a supersonic nozzle, a knife edge, and a pulsed laser light source (radiation unit).

2 3 2 3 3 The vacuum vesselis a vessel having a vacuum internal space. The supersonic nozzleis a nozzle that ejects, into an internal space of the vacuum vessel, the supersonic gas flow G toward the Z direction which is a first direction. That is, the supersonic nozzlegenerates the supersonic gas flow G flowing along the Z direction under a vacuum atmosphere in the vacuum. The supersonic gas flow G is a flow of a gas (a gas flow) flowing at supersonic speed. For example, hydrogen gas can be used as the supersonic gas flow G. The supersonic nozzleis not particularly limited, and an axisymmetric conical nozzle can be used.

1 2 FIGS.and 3 31 32 33 34 31 32 33 34 31 31 3 As illustrated in, the supersonic nozzleincludes a throat, a divergence portion, a convergence portion, and a flow straightening chamber. The throat, the divergence portion, the convergence portion, and the flow straightening chamberflows a gas in the Z direction. The throatchokes a flow of a flowing gas. The throatis a part having the smallest flow channel cross-sectional area in the supersonic nozzle.

32 31 31 32 31 32 32 33 31 31 33 31 33 The divergence portionis a portion having an upstream end forming the throatand a downstream end having a flow channel cross-sectional area larger than a cross-sectional area of the throat. The divergence portionallows a flow of a gas choked at the throatto diverge. The divergence portionhas a circular flow channel cross section. The downstream end of the divergence portionforms an outlet of the supersonic gas flow G. The convergence portionis a portion having a downstream end forming the throatand an upstream end having a flow channel cross-sectional area larger than a cross-sectional area of the throat. The convergence portionallows a flow of a gas to converge toward the throat. The convergence portionhas a circular flow channel cross section.

34 33 34 33 34 34 34 33 The flow straightening chamberis a portion that is smoothly connected to the upstream end of the convergence portionand extend by a predetermined length. The flow straightening chamberhas a circular flow channel cross section and has a diameter equal to that of the upstream end of the convergence portion. The flow straightening chamberlinearly extends in the Z direction, and has a constant flow channel cross-sectional area in the Z direction. The flow straightening chamberhas a function of straightening a flow of a gas in the Z direction. The flow straightening chambermay have a predetermined length of 10 mm or longer, 20 mm or longer, or 30 mm or longer. The predetermined length in this embodiment is 20 mm. For example, the predetermined length of 10 mm or longer corresponds to three times or more a length of the convergence portionin the Z direction.

3 61 62 63 64 3 61 61 61 61 31 32 33 61 The supersonic nozzleis configured to be dividable into an upper end member, a first middle member, a second middle member, and a bottom member. The supersonic nozzleis made of, for example, stainless steel or titanium. The upper end memberis a member having a cylindrical partA having an axial direction parallel to the Z direction, and a disk-shaped flangeB which is provided at an upstream end portion of the cylindrical partA and has an axial direction parallel to the Z direction. The throat, the divergence portion, and the convergence portionare formed at an axial center position inside the upper end member.

62 63 34 62 62 61 61 62 61 65 34 63 63 62 63 62 66 The first middle memberand the second middle memberare disk-shaped members having an axial direction parallel to the Z direction. The flow straightening chamberhas a downstream part formed at an axial center position inside the first middle member. The first middle memberis coaxially fixed to overlap the flangeB of the upper end member. The first middle memberis positioned with respect to the flangeB via a positioning portion. The flow straightening chamberhas a midstream part formed at an axial center position inside the second middle member. The second middle memberis coaxially fixed to overlap the first middle member. The second middle memberis positioned with respect to the first middle membervia a positioning portion.

64 64 64 64 34 69 64 64 63 64 63 67 69 34 69 The bottom memberis a member having a circular columnar partA having an axial direction parallel to the Z direction, and a disk-shaped flangeB which is provided at an upstream end portion of the circular columnar partA and has an axial direction parallel to the Z direction. The flow straightening chamberhas an upstream part and an introduction channelformed at an axial center position inside the bottom member. The bottom memberis coaxially fixed to overlap the second middle member. The bottom memberis positioned with respect to the second middle membervia a positioning portion. The introduction channelis a flow channel in which a gas is introduced in the Z direction into the flow straightening chambervia a valve (not illustrated) such as an electromagnetic valve. The introduction channelextends in the Z direction.

3 69 34 33 31 32 2 In the supersonic nozzledescribed above, the gas is introduced into the introduction channelby opening the valve, and the gas flows to the flow straightening chamberand the convergence portionin this order. Then, the gas passes through the throatand the divergence portionto be accelerated from a subsonic speed to a supersonic speed, and the supersonic gas flow G is ejected in the Z direction into the internal space of the vacuum vessel.

1 3 FIGS.and 4 4 4 4 3 4 7 4 3 4 3 As illustrated in, the knife edgeis inserted into the supersonic gas flow G from one side (left side in the drawing) in the X direction which is a second direction intersecting the first direction. The knife edgeis a knife-shaped member and has a sharp pointed tip shape. The knife edgeis also referred to as a blade. The knife edgehas a tip portion inclined toward the supersonic nozzlewith respect to the X direction. The knife edgeis fixed to a basevia a support member (not illustrated), for example. This allows the knife edgeto be supported in a state in which a positional relationship with the supersonic nozzleis maintained constant. For example, the knife edgemay be disposed at a distance of 1.5 mm, 2.0 mm, or 2.5 mm away from the supersonic nozzlein the Z direction.

4 4 3 The knife edgeforms, in the supersonic gas flow G, a shock wave I starting from the tip portion thereof. The shock wave I has a wavefront from the tip portion of the knife edgetoward a side downstream in the supersonic gas flow G and toward the other side in the X direction, for example. Here, the shock wave I is not an arcuate shock wave but a linear oblique shock wave inclined to the other side in the X direction with respect to the Z direction as being away from the supersonic nozzle. A steeply falling part of a gas density distribution of the supersonic gas flow G in the X direction corresponds to the shock wave I. Hereinafter, the gas density distribution of the supersonic gas flow G is also simply referred to as a “gas density distribution”.

4 4 4 3 4 4 3 4 4 4 4 4 3 a a b The knife edgeis inserted into the supersonic gas flow G from the one side in the X direction, thereby causing the gas density distribution of the supersonic gas flow G in the X direction to become a distribution that rises steeply, falls steeply, and then is maintained within a certain range from the one side toward the other side in the X direction. When viewed from the Y direction, a surfaceof the tip portion of the knife edgeon the supersonic nozzleside has an angle α of 30° to 45° with respect to the X direction. When viewed from the Y direction, a tip angle β of the tip portion of the knife edge(an angle between the surfaceon the supersonic nozzleside and a surfaceon the opposite side: an angle of a knife edge) is 14° to 28°. In this embodiment, the angle α is 30°, and the tip angle β is 14°. The knife edgehas a thickness to the extent that a certain level of vibration or higher do not occur in a case where the knife edgeis inserted into the supersonic gas flow G. A shape of the knife edgeand a positional relationship of the knife edgewith the supersonic nozzleare not particularly limited, and may have various shapes and positional relationships as long as the gas density distribution described above is formed.

1 FIG. 5 5 4 As illustrated in, the pulsed laser light sourceradiates the pulsed laser light L in the X direction into the supersonic gas flow G from the one side in the X direction, and propagates the pulsed laser light to pass through the shock wave I in the supersonic gas flow G. The pulsed laser light sourceradiates the pulsed laser light L in the X direction to pass through a side downstream in the supersonic gas flow G from the knife edgein the supersonic gas flow G. The radiation of the pulsed laser light L causes plasma wave crushing to occur at the shock wave I, and the plasma wave crushing causes the electron beam E having directionality toward the other side in the X direction to be generated.

1 Next, an electron beam generation method for generating the electron beam E by the above-described electron beam generation apparatuswill be described.

3 69 3 34 33 31 32 3 34 33 31 32 2 2 First, the valve of the supersonic nozzleis opened from a state of being closed, a gas is supplied at a predetermined pressure from outside to the introduction channelof the supersonic nozzle, and the gas flows along the Z direction through the flow straightening chamber, the convergence portion, the throat, and the divergence portion. In the supersonic nozzle, the gas from outside flows along the Z direction through the flow straightening chamberfor a predetermined length, then the gas converges while flowing along the first direction in the convergence portion, the flow of the gas is choked in the throat, and the gas diverges while flowing along the first direction in the divergence portion. This causes the supersonic gas flow G to be ejected along the Z direction into the internal space of the vacuum vessel. That is, the supersonic gas flow G flowing along the Z direction under the vacuum atmosphere of the vacuum vesselis generated (a first step).

4 4 In the first step, the knife edgeis inserted into the supersonic gas flow G from the one side in the X direction. This causes the shock wave I to be formed in the supersonic gas flow G from the tip of the knife edge(a second step).

5 Subsequently, the pulsed laser light L is radiated from the pulsed laser light sourcealong the X direction into the supersonic gas flow G from the one side in the X direction, and the pulsed laser light L is propagated to pass through the shock wave I in the supersonic gas flow G. This causes a plasma wave to be crushed at a generation position of the shock wave I, that is, a part where the gas density distribution of the supersonic gas flow G in the X direction steeply falls, and the electron beam E is instantaneously generated (a third step). The generated electron beam E travels to the other side in the X direction and is accelerated to have a high energy in an acceleration region (a region where the gas density distribution is maintained within a certain range on the other side in the X direction with respect to the peak in the gas density distribution) in the supersonic gas flow G. Then, the accelerated electron beam E is radiated to the target subject.

Here, as a result of close studies, the present inventors have found that the stability of the electron beam E is significantly affected by the stability of the gas density distribution of the supersonic gas flow G. In addition, the present inventors have found that performance (a parameter) of the electron beam E is sensitive to the gas density distribution of the supersonic gas flow G. Specifically, the present inventors have found that, when the gas density distribution to be formed is unstable, and a positional relationship between a condensing point of the pulsed laser light L and a shock front is unstable, reproducibility and stability of the generated electron beam E are not good.

1 3 34 3 34 In this respect, in the electron beam generation apparatusand the electron beam generation method according to this embodiment, the supersonic nozzlehas the flow straightening chamber. In the supersonic gas flow G generated by the supersonic nozzle, the flow straightening chamberenables non-linear instability due to fluid boundary effects to be effectively reduced, enables generation of a turbulent flow (uncertainty in turbulent motion) to be curbed, and enables the stability of the gas density distribution to be enhanced. This enables the stability of the electron beam E to be enhanced. The probability of generation of the electron beam E with respect to a shot (radiation) of the pulsed laser light L can be increased, and reproducibility of an energy spectrum of the electron beam E for each shot of the pulsed laser light L can be increased. Variations in charge or the like of the electron beam E can be curbed.

1 33 34 34 3 3 In the electron beam generation apparatusand the electron beam generation method, the convergence portionand the flow straightening chamberextend along the Z direction, and a predetermined length thereof is 20 mm or longer. In this case, the flow straightening chamberof the supersonic nozzleenables, for example, the generation of a turbulent flow in the supersonic gas flow G generated by the supersonic nozzleto be reliably curbed and enables the stability of the gas density distribution to be reliably enhanced.

1 4 3 4 3 4 4 In the electron beam generation apparatusand the electron beam generation method, at least the tip portion of the knife edgeis inclined toward the supersonic nozzlewith respect to the X direction. At least the tip portion of the knife edgeis inclined toward the supersonic nozzle, thereby enabling the shock wave I linearly extending from the tip of the knife edgeto be formed in the supersonic gas flow G. In this case, a generation position of the electron beam E in the supersonic gas flow G can be stabilized, and the stability of the electron beam E can be enhanced. A shape of the shock wave I can be controlled depending on a shape of at least the tip portion of the knife edge.

1 3 34 34 In the electron beam generation apparatusand the electron beam generation method, the supersonic nozzleis configured to be dividable such that the flow straightening chamberis divided. In this case, the flow straightening chamberhaving a long length can be easily formed.

4 FIG. 5 FIG. 6 FIG. 4 5 6 a a a FIG.(),(), and() 4 5 b b FIG.(),() 3 34 3 34 3 34 6 b is a diagram illustrating a flow of a gas inside the supersonic nozzlein a case where the flow straightening chamberhas a predetermined length of 10 mm.is a diagram illustrating a flow of a gas inside the supersonic nozzlein a case where the flow straightening chamberhas a predetermined length of 20 mm.is a diagram illustrating a flow of a gas inside the supersonic nozzlein a case where the flow straightening chamberhas a predetermined length of 30 mm.illustrate hydrodynamic simulation results of gas velocity streamlines, and, and() illustrate hydrodynamic simulation results of eddy viscosities of the gas.

4 4 5 5 6 6 a b a b a b FIG.(),(),(),(),(), and() 34 As illustrated in, it can be found that the flow straightening chambershaving the predetermined lengths of 10 mm, 20 mm, and 30 mm enable the instability of the flow of the gas to be reduced, enables the gas to flow in a laminar flow along the Z direction, and enables the gas in a turbulent flow to be scattered. In this embodiment, it can be found that effects of reducing the instability of a flow of a gas are remarkable when the predetermined length is 20 mm or longer.

7 a FIG.() 7 b FIG.() 7 7 a b FIG.() and() 1 34 is a graph illustrating a directional distribution of the electron beams E in a first example.is a graph illustrating a directional distribution of the electron beams E in a first comparative example. The first example corresponds to the electron beam generation apparatusaccording to the first embodiment, and the first comparative example corresponds to an electron beam generation apparatus similar to the first embodiment except that the flow straightening chamberis not provided (the same applies to the followings). In, the horizontal axis represents the directionality (mrad) in the X direction, and the vertical axis represents the directionality (mrad) in the Y direction. The results in the drawings are obtained by radiating 20 shots of the pulsed laser light L.

7 a FIG.() 7 b FIG.() According to the first example, as illustrated in, the directivity of the electron beams E does not vary and is stable, and the stability of the electron beams E can be enhanced. On the other hand, in the first comparative example, as illustrated in, it can be found that variations in directivity of the electron beams E (for example, a standard deviation of ten times or more) occur, and there is a concern that the stability of the electron beam E will be impaired.

8 a FIG.() 8 b FIG.() 8 8 a b FIG.() and() 3 3 18 −3 is a graph illustrating a density profile of the supersonic gas flow G in the vicinity of an outlet of the supersonic nozzlein the first example.is a graph illustrating a density profile of the supersonic gas flow G in the vicinity of an outlet of a supersonic nozzle in the first comparative example. In, the horizontal axis represents a position (mm) in the X direction, and the vertical axis represents a gas density (n/10cm). Differences in line type in both the drawings indicate differences in height from a front surface of the supersonic nozzle.

8 a FIG.() 8 b FIG.() 3 3 X According to the first example, as illustrated in, the density profiles are symmetrical in the X direction, and peaks of the density profiles are gentle (a range in the X direction in which a gas density is high is wide). According to the first example, it can be found that the density profiles tend to be the same and stable even in a case where heights from the front surface of the supersonic nozzleare different. On the other hand, in the first comparative example, as illustrated in, the density profile is asymmetric in thedirection, and the peak of the density profile is also relatively sharp. In the first comparative example, it can be found that, in a case where the heights from the front surface of the supersonic nozzleare different, the density profiles may tend to be different, and there is a concern that the density profiles will become unstable.

9 a FIG.() 9 b FIG.() 9 9 a b FIGS.() and() 3 is a graph illustrating density profiles of the shock waves I in the first example.is a graph illustrating density profiles of shock waves in the first comparative example. In, the horizontal axis represents a position (mm) in the X direction, and the vertical axis represents a relative value (n/n0) of a gas density. Differences in line type in both the drawings indicate perturbations in nozzle outlets with respect to a pressure of the gas supplied to the supersonic nozzle.

9 a FIG.() 9 b FIG.() 3 3 According to the first example, as illustrated in, even when the perturbations in the nozzle outlets with respect to the pressure of the gas supplied to the supersonic nozzleare different, the density profiles do not vary and are stable, and a distribution deviation is almost 0. On the other hand, in the first comparative example, as illustrated in, it can be found that, in a case where the perturbations in the nozzle outlets with respect to the pressure of the gas supplied to the supersonic nozzleare different, the density profiles may vary, and there is a concern that the distribution deviation will be, for example, 30 μm or more.

10 a FIG.() 10 b FIG.() 10 10 a b FIG.() and() 10 10 a b FIG.() and() 4 4 is a diagram illustrating a density distribution of the supersonic gas flow G in the first example.is a diagram illustrating a density distribution of the supersonic gas flow G in a second comparative example.illustrate hydrodynamic simulation results. In, the density distributions of the supersonic gas flow G are visualized by shading of a color. The second comparative example corresponds to an electron beam generation apparatus similar to that of the first embodiment except that an entire knife edgeJ (including a tip portion) extending in the X direction is provided instead of the knife edge.

10 a FIG.() 10 b FIG.() 4 4 4 I According to the first example, as illustrated in, the shock wave I is not an arcuate shock wave but an oblique shock wave linearly extending from the tip of the knife edge. In this case, the gas can be prevented from remaining (stagnating) in a region formed by the shock wave I and the tip portion of the knife edge, and the position of the shock wave I can be prevented from becoming unstable due to an effect of the remaining. As a result, the position of the shock wave I becomes more stable, and the parameter (pointing, an energy spectrum, a charge amount, or the like) of the electron beam E can be stabilized. On the other hand, in the second comparative example, as illustrated in, the shock waveis an arcuate shock wave. In this case, it can be found that a gas may remain in the region formed by the shock wave I and the tip portion of the knife edge, and there is a concern that position of the shock wave I will become unstable.

11 FIG. 11 FIG. 11 FIG. 1 is a graph illustrating density profiles of shock waves I in the first example and the second comparative example. In, the horizontal axis represents a position (mm) in the X direction, and the vertical axis represents a relative value (n/n0) of a gas density. As illustrated in, it can be found that, in the first example, a height of a peak in a gas density distribution of the supersonic gas flow G can be increased as compared with the second comparative example, and the shock wave I becomes sharp. That is, in the electron beam generation apparatus, the strong shock wave I can be stably formed in the supersonic gas flow G.

Next, a second embodiment will be described. In the description of this embodiment, differences from the first embodiment will be described, and redundant descriptions will be omitted.

103 8 3 12 FIG. 2 FIG. An electron beam generation apparatus according to the second embodiment differs from that of the first embodiment in that a supersonic nozzlehaving a mesh member (flow straightening member)is provided as illustrated ininstead of the supersonic nozzle(see).

8 34 8 34 8 34 34 8 34 63 64 64 The mesh memberis provided inside the flow straightening chamber. In the mesh member, a plurality of fine holes are formed along the Z direction which is a flow direction of the flow straightening chamber. The mesh memberis disposed inside the flow straightening chamberat a distance of 5 mm or longer from an upstream end and a downstream end of the flow straightening chamber. In the illustrated example, the mesh memberis provided inside the flow straightening chamberto be sandwiched between the second middle memberand the circular columnar partA of the bottom member.

13 FIG. 8 8 8 8 As illustrated in, the mesh memberhas a knitting structure in which linear members having a circular cross section are arranged in the X direction and the Y direction at predetermined intervals. A diameter of a cross section of the mesh memberis, for example, 0.1 mm, and the predetermined interval is, for example, 0.2 mm. The mesh memberis made of, for example, stainless steel. The mesh membermay be made of a material having a certain level of hardness or higher instead of stainless steel.

8 8 8 The electron beam generation apparatus and an electron beam generation method according to the second embodiment are also capable of enhancing the stability of the electron beam E. In addition, a flow rectification of the mesh memberenables, for example, the generation of a turbulent flow in the supersonic gas flow G to be further curbed and enables the stability of the gas density distribution to be further enhanced. Since the mesh memberhas a net structure, a pressure difference generated between sides upstream and downstream of the mesh membercan be reduced while a sufficient flow rectification is ensured.

8 34 34 8 34 8 34 8 In the electron beam generation apparatus and the electron beam generation method according to the second embodiment, the mesh memberis disposed inside the flow straightening chamberat a distance of 5 mm or longer from the upstream end or the downstream end of the flow straightening chamber. In this case, since the mesh memberis sufficiently separated from the upstream end or the downstream end of the flow straightening chamber, the flow rectification of the mesh membercan be prevented from being insufficiently exerted due to an effect of the upstream end or the downstream end of the flow straightening chamber, and the flow rectification of the mesh membercan be reliably exhibited.

14 a FIG.() 14 b FIG.() 14 14 a b FIG.() and() 14 14 a b FIG.() and() 14 a FIGS.() 3 3 14 34 8 b is a diagram illustrating a density distribution of a gas inside a supersonic nozzlein a second example.is a diagram illustrating the density distribution of the gas inside the supersonic nozzlein the first example. The second example corresponds to the electron beam generation apparatus according to the second embodiment.illustrate hydrodynamic simulation results. In, the density distributions of the gas are visualized by shading of a color. As illustrated inand(), it can be found that the flow of the gas can be further straightened inside the flow straightening chamberby the mesh member.

34 34 3 In the second embodiment, the flow straightening chambermay have a predetermined length of 10 mm or longer. Also in this case, the flow straightening chamberenables, for example, the generation of a turbulent flow in the supersonic gas flow G generated by the supersonic nozzleto be reliably curbed and enables the stability of the gas density distribution of the supersonic gas flow G to be reliably enhanced.

15 FIG. 201 As illustrated in, an electron beam generation apparatusis an apparatus that generates an electron beam E for being radiated to a target subject. The target subject is not particularly limited, and examples thereof include a prodrug in a patient's body. In this case, the electron beam E acts as a trigger for changing the prodrug in the patient's body into an active substance. The prodrug is not particularly limited, and examples thereof include a prodrug that passes through the blood-brain barrier (a mechanism that restricts transit of a substance from blood to brain tissue).

201 201 201 202 203 204 205 206 The electron beam E generated by the electron beam generation apparatusmay have an energy higher than 1 MeV, an energy higher than 10 MeV, or an energy higher than 200 MeV. In a case where the target subject is a patient, the electron beam E may have an energy higher than 10 MeV. The electron beam generation apparatusaccording to this embodiment generates the electron beam E by propagating pulsed laser light L in a supersonic gas flow G. The electron beam generation apparatusincludes a vacuum vessel, a supersonic nozzle, a knife edge, a pulsed laser light source (radiation unit), and a back plate (plate member).

202 203 202 203 203 The vacuum vesselis a vessel having a vacuum internal space. The supersonic nozzleis a nozzle that ejects, into an internal space of the vacuum vessel, the supersonic gas flow G toward the Z direction which is a first direction. That is, the supersonic nozzlegenerates the supersonic gas flow G flowing along the Z direction under a vacuum atmosphere in the vacuum. The supersonic gas flow G is a flow of a gas (a gas flow) flowing at supersonic speed. For example, hydrogen gas can be used as the supersonic gas flow G. For example, as the supersonic nozzle, an axially asymmetric Laval nozzle can be used.

15 16 FIGS.and 203 231 207 231 232 233 232 234 232 203 233 235 233 235 235 233 235 233 As illustrated in, the supersonic nozzlehas a nozzle bodyfixed on a base. The nozzle bodyincludes a throatthat chokes a flow of a flowing gas, a gas flow channelin which the gas flows from the outside to the throat, and an openingforming an outlet of the supersonic gas flow G. The throatis a part having the smallest flow channel cross-sectional area in the supersonic nozzle. The gas flow channelincludes two bent portionsthat bend, toward the X direction which is the second direction, the flow of the gas flowing along the Z direction. Specifically, the gas flow channelincludes, as the bent portions, a first bent portionA provided on a side upstream of the gas flow channeland a second bent portionB provided on a side downstream of the gas flow channel.

233 233 233 233 233 233 231 208 233 233 233 235 233 233 233 233 233 233 235 233 233 232 233 233 234 234 232 The gas flow channelincludes an introduction channelA, a first chicane channelB, a middle channelC, and a second chicane channelD in this order from the side upstream to the side downstream therein. The introduction channelA is a flow channel that allows the gas to be introduced into the nozzle bodyvia a valvesuch as an electromagnetic valve. The introduction channelA extends along the Z direction. The first chicane channelB is a flow channel that communicates with a downstream side of the introduction channelA via the first bent portionA. The first chicane channelB extends along the X direction. The middle channelC communicates with a downstream side of the first chicane channelB. The middle channelC extends along the Z direction. The second chicane channelD communicates with a downstream side of the middle channelC via the second bent portionB. The second chicane channelD extends along the X direction. A midstream part of the second chicane channelD communicates with the throat. A buffer portionQ is provided at a downstream end portion of the second chicane channelD. The openingis a U-shaped cutout when viewed from the Y direction. The openingcommunicates with the throat.

203 208 233 233 233 233 233 233 232 234 202 In the supersonic nozzle, when the valveis opened, the gas is introduced into the introduction channelA of the gas flow channel, and the gas flows through the first chicane channelB, the middle channelC, and the second chicane channelD in this order. Then, the gas reaching the second chicane channelD passes through the throatto be accelerated from a subsonic speed to a supersonic speed, and the supersonic gas flow G is ejected along the Z direction from the openinginto an internal space of the vacuum vessel.

204 204 204 204 204 207 204 203 The knife edgeis inserted into the supersonic gas flow G from one side in the X direction (a left side in the drawing). The knife edgeis a knife-shaped member having a long length in the X direction and has a sharp pointed tip shape. The knife edgeforms, in the supersonic gas flow G, a shock wave I starting from the tip portion thereof. The shock wave I has a wavefront from the tip portion of the knife edgetoward a side downstream in the supersonic gas flow G and toward the other side in the X direction, for example. The knife edgeis fixed to the basevia a support member (not illustrated), for example. This allows the knife edgeto be supported in a state in which a positional relationship with the supersonic nozzleis maintained constant.

15 21 FIGS.and 204 204 204 203 As described in, the knife edgedescribed above is inserted into the supersonic gas flow G from the one side in the X direction, thereby causing the gas density distribution of the supersonic gas flow G in the X direction to become a distribution that rises steeply, falls steeply, and then is maintained within a certain range from the one side toward the other side in the X direction. A shape of the knife edgeand a positional relationship of the knife edgewith the supersonic nozzleare not particularly limited, and may have various shapes and positional relationships as long as the gas density distribution described above is formed.

A part D in which the gas density distribution in the X direction steeply falls corresponds to the shock wave I. A position at which the gas density distribution in the X direction steeply rises and steeply falls is a peak, and a region (flat region) where the gas density distribution is maintained within a certain range on the other side in the X direction from the peak is an acceleration region AC. In the acceleration region AC, the generated electron beam E can be accelerated. The part D in which the gas density distribution steeply falls is also referred to as a shock front.

205 205 204 15 19 FIGS.and The pulsed laser light sourceradiates the pulsed laser light L along the X direction into the supersonic gas flow G from the one side in the X direction, and propagates the pulsed laser light to pass through the shock wave I in the supersonic gas flow G. The pulsed laser light sourceradiates the pulsed laser light L along the X direction to pass through a side downstream in the supersonic gas flow G from the knife edgein the supersonic gas flow G. As illustrated in, the radiation of the pulsed laser light L described above causes plasma wave crushing to occur at the shock wave I, and the plasma wave crushing causes the electron beam E having directionality toward the other side in the X direction to be generated.

15 17 19 FIGS.,, and 206 206 206 203 206 203 206 As illustrated in, the back plateis a flat plate-shaped member that is elongated in the Z direction and has a thickness direction parallel to the X direction. For example, the back plateis made of stainless steel and has a thickness of 2 mm. The back plateis disposed by the other side of the supersonic nozzlein the X direction (the right side in the drawing). In this embodiment, a base end side of the back plateis fixed to the supersonic nozzleon the other side in the X direction with a screw or the like. The back plateis also referred to as a rear plate.

206 206 203 206 6 203 206 203 206 206 206 206 206 206 206 x x x The back plateextends along a boundary plane GB of the supersonic gas flow G on the other side in the X direction. The back plateis disposed without a gap with respect to the supersonic nozzlein the X direction. A surface of the back plateon the supersonic gas flow G side is a flat surface. The back plateprojects in the Z direction from the supersonic nozzlebeyond a condensing point LS of the pulsed laser light L. A through-holehaving a circular cross section is formed to penetrate a tip portion (an end portion on a side away from the supersonic nozzle) of the back platealong the X direction. The through-holeis a hole through which the generated electron beam E passes. The back plateis positioned on the other side in the X direction with respect to the condensing point LS of the pulsed laser light L. In other words, the condensing point LS of the pulsed laser light L is positioned on the one side in the X direction with respect to the back plate. An end of the back plateand a side edge of the through-holeare chamfered, and the end of the back plateand the side edge of the through-hole 206x are rounded.

1 18 21 FIGS.to Next, the electron beam generation method for generating the electron beam E by the above-described electron beam generation apparatuswill be described with reference to.

18 19 20 FIGS.,, and 21 FIG. 18 19 20 FIGS.,, and 18 19 20 FIGS.,, and 21 FIG. 23 24 FIGS.and 203 1 2 203 are diagrams illustrating respective states in the supersonic gas flow G for description of the electron beam generation method.is a graph illustrating a gas density distribution of the supersonic gas flow G in the X direction. In, the flow of the supersonic gas flow G is visualized by, for example, the Schlieren method.illustrate respective states obtained by viewing the periphery of the supersonic nozzlefrom the Y direction. In these drawings, the formed shock wave I may be represented by a broken line for convenience of display. In, the horizontal axis represents a position in the X direction, and the vertical axis represents a gas density. A range from a position Xto a position Xin the X direction corresponds to a range in the X direction in which the supersonic nozzleis provided (the same applies toto be described below).

208 203 232 233 203 232 203 233 233 203 202 202 204 204 206 203 206 18 FIG. First, the valveof the supersonic nozzleis opened from a closed state, and the gas flows from the outside to the throatalong the gas flow channelin the supersonic nozzle. When the gas flows to the throat, the supersonic nozzlecauses the flow of the gas to be bent at least once toward the X direction by the first chicane channelB and the second chicane channelD. As illustrated in, the supersonic gas flow G is ejected along the Z direction from the supersonic nozzleinto the internal space of the vacuum vessel(under a vacuum atmosphere). This causes the supersonic gas flow G flowing along the Z direction to be generated in the internal space of the vacuum vessel(the first step). At this time, the knife edgeis inserted into the supersonic gas flow G from the one side in the X direction. This causes the shock wave I to be formed in the supersonic gas flow G from the tip of the knife edge(the second step). In the second step, the back plateis disposed on the other side of the supersonic nozzlein the X direction, and the back plateextends along the boundary plane GB of the supersonic gas flow G.

19 FIG. 20 21 FIGS.and 205 206 206 206 206 x x Subsequently, as illustrated in, the pulsed laser light L is radiated from the pulsed laser light sourcealong the X direction into the supersonic gas flow G from the one side in the X direction, and the pulsed laser light L is propagated to pass through the shock wave I in the supersonic gas flow G. As illustrated in, this causes a plasma wave to be crushed at a generation position of the shock wave I, that is, a part D where the gas density distribution of the supersonic gas flow G in the X direction steeply falls, and the electron beam E is instantaneously generated (the third step). The generated electron beam E travels to the other side in the X direction and is accelerated to have a high energy in a region until the electron beam E passes through the through-holeof the back plate, that is, the acceleration region AC in the supersonic gas flow G. Then, the accelerated electron beam E passes through the through-holeof the back plateand then is radiated to a target subject (not illustrated).

Here, as a result of close studies, the present inventors have found that the stability of the electron beam E is significantly affected by the stability of the gas density distribution of the supersonic gas flow G. In addition, the present inventors have found that performance (a parameter) of the electron beam E is sensitive to the gas density distribution of the supersonic gas flow G. Specifically, it has been found that, when the gas density distribution to be formed is unstable, and the positional relationship between the condensing point LS of the pulsed laser light L and the shock front is unstable, the reproducibility and stability of the generated electron beam E are not good. In addition, it has been found that position stability of a peak of a density is not good in a case where the peak of the gas density distribution is small (the shock wave I is weak) and in a case where the shock front has a gentle gradient.

201 206 206 203 204 x In this respect, in the electron beam generation apparatusand the electron beam generation method according to this embodiment, the back platehaving the through-holeenables spreading of the supersonic gas flow G ejected from the supersonic nozzleto a side opposite to the side on which the knife edgeis inserted (the other side in the X direction) to be curbed without interference with the generated electron beam E. This enables a strong shock wave I to be stably formed in the supersonic gas flow G. The peak of the gas density distribution can be increased, and the shock front can have a steep gradient. Improvement of ten times or more in the position stability of the peak in the gas density distribution can be achieved, for example. A constant positional relationship between the condensing point LS of the pulsed laser light L and the shock front can be maintained constant. As a result, the stability of the gas density distribution can be enhanced, and the stability and the reproducibility of the electron beam E can be enhanced. The probability of generation of the electron beam E with respect to the shot (radiation) of the pulsed laser light L can be increased, and the reproducibility of an energy spectrum of the electron beam E for each shot of the pulsed laser light L can be increased. Variations in charge or the like of the electron beam E can be curbed.

203 204 203 232 In order to enhance the stability and the reproducibility of the electron beam E, the gas density distribution of the supersonic gas flow G generated by the supersonic nozzleis desirably uniform in the X direction which is a propagation direction of the pulsed laser light L in a state in which the knife edgeis not inserted. However, when the gas directly flows from the outside of the supersonic nozzleto the throat, a flow velocity of the gas in a central portion in the X direction becomes faster and a density thereof becomes smaller in the generated supersonic gas flow G, and there is a possibility that the gas density distribution will not be uniform in the X direction.

201 233 203 201 233 232 203 235 232 203 203 203 232 232 232 In this regard, in the electron beam generation apparatus, a gas loading structure in the gas flow channelwhich is a reservoir unit (reservoir tank) of the supersonic nozzleis improved. That is, in the electron beam generation apparatus, the gas flow channelthrough which the gas flows from the outside to the throatin the supersonic nozzlehas at least one bent portionat which the flow of the gas is bent toward the X direction. In the electron beam generation method, in a step of allow the gas to flow from the outside to the throatof the supersonic nozzle, the flow of the gas in the supersonic nozzleis bent at least once toward the X direction. This enables the gas from the outside of the supersonic nozzleto be prevented from flowing directly to the throat, enables the flow velocity of the gas flowing to the throatto be decreased, and enables the momentum of the gas in the throatto approach zero. As a result, the gas density distribution can be made uniform in the X direction.

201 233 235 235 233 235 233 232 In the electron beam generation apparatus, the gas flow channelincludes, as the bent portions, the first bent portionA provided on a side upstream of the gas flow channeland the second bent portionB provided on a side downstream of the gas flow channel. In this case, the flow velocity of the gas flowing through the throatcan be effectively decreased, and the gas density distribution can be effectively made uniform in the X direction.

201 204 204 In the electron beam generation apparatus, the knife edgecauses the gas density distribution of the supersonic gas flow G in the X direction to become a distribution that rises steeply, falls steeply, and then is maintained within a certain range from the one side toward the other side in the X direction. In this case, the insertion of the knife edgeinto the supersonic gas flow G from the one side in the X direction enables the gas density distribution of the supersonic gas flow G which is suitable for generating the electron beam E to be formed.

201 201 The electron beam generation apparatuscauses the plasma wave crushing to occur at the shock wave I in the supersonic gas flow G by the pulsed laser light L, and generates the electron beam E by the plasma wave crushing. As described above, in the electron beam generation apparatus, the electron beam E can be generated using the plasma wave crushing.

201 The electron beam generation apparatusaccelerates the generated electron beam E in the acceleration region AC in which the gas density distribution of the supersonic gas flow G in the X direction is maintained within the certain range. In this case, the generated electron beam can be accelerated to have the high energy by using the acceleration region AC having a size of about several centimeters.

201 206 206 201 205 206 205 206 x x In the electron beam generation apparatus, the condensing point LS of the pulsed laser light L is positioned on the one side in the X direction from the back plate. In this case, adverse effects of the condensing of the pulsed laser light L on the back platecan be curbed. In the electron beam generation apparatus, the pulsed laser light sourceradiates the pulsed laser light L along the X direction into the supersonic gas flow G from the one side in the X direction. The through-holepenetrates the back plate in the X direction. In this case, the pulsed laser light sourceand the through-holecan be specifically formed.

22 22 a b FIGS.() and() 22 a FIG.() 22 b FIG.() 22 22 a b FIGS.() and() 22 22 a b FIGS.() and() 201 201 206 232 235 203 201 are graphs illustrating variations in position of the shock front when the electron beam E is repeatedly generated.illustrates data according to a third comparative example, andillustrates data according to a third example which is the electron beam generation apparatus. The third comparative example differs from the electron beam generation apparatusin that the back plateis not provided, and a supersonic nozzle through which a gas directly flows to the throatwithout the bent portionis provided instead of the supersonic nozzle. Except for that, the third comparative example has the same configuration as that of the electron beam generation apparatus. In, the vertical axis represents a relative value of a gas density of the supersonic gas flow G, and the horizontal axis represents a position in the X direction. Both waveforms incorrespond to results when the electron beam E is repeatedly generated.

22 a FIG.() 22 b FIG.() 201 206 201 As illustrated in, in the case of the comparative example, the position of the shock front in the X direction varies in a range of 60 μm, for example. On the other hand, as illustrated in, in the electron beam generation apparatusincluding the back plate, variations in the position of the shock front in the X direction can be curbed, and the variations can converge within a range of 25 μm, for example. This can confirm that the position stability of the peak of the gas density distribution can be improved in the electron beam generation apparatus.

23 23 a b FIGS.() and() 23 a FIG.() 23 b FIG.() 23 23 a b FIGS.() and() 23 23 a b FIGS.() and() 201 201 1 are graphs illustrating the gas density distribution of the supersonic gas flow G in the X direction.illustrates data according to the third comparative example, andillustrates data according to the third example which is the electron beam generation apparatus. In, the vertical axis represents a gas density of the supersonic gas flow G, and the horizontal axis represents a position in the X direction. As illustrated in, it can be found that, in the electron beam generation apparatus, a height of a peak (a shock wave) in the gas density distribution of the supersonic gas flow G can be increased as compared with the third comparative example. This can confirm that, in the electron beam generation apparatus, the strong shock wave I is stably formed in the supersonic gas flow G, and the position stability of the peak in the gas density distribution can be improved.

24 24 a b FIGS.() and() 24 a FIG.() 24 b FIG.() 24 24 a b FIGS.() and() 204 201 are exemplary graphs illustrating the gas density distributions of the supersonic gas flow G in the X direction in a state before the knife edgeis inserted.illustrates data according to a fourth comparative example, andillustrates data according to the third example which is the electron beam generation apparatus. In, the vertical axis represents a gas density of the supersonic gas flow G, and the horizontal axis represents a position in the X direction.

24 a FIG.() 24 b FIG.() 201 As illustrated in, in the fourth comparative example, the gas density distribution of the supersonic gas flow G in the X direction is not uniform and has a waveform recessed at a central portion thereof. On the other hand, as illustrated in, in the electron beam generation apparatus, it has been confirmed that the gas density distribution of the supersonic gas flow G in the X direction can be made uniform.

201 233 233 232 201 206 206 x, The electron beam generation apparatusincludes the buffer portionQ. The buffer portionQ further prevents the gas from flowing directly to the throat, and the gas density distribution of the supersonic gas flow G can be made more uniform in the X direction. In the electron beam generation apparatus, chamfering is performed on the end of the back plateand the side edge of the through-holethereby enabling the generation of shock waves due to burrs to be curbed.

201 206 203 206 In the electron beam generation apparatus, the back platemay have a certain thickness or more and certain strength or higher so as not to vibrate when the supersonic gas flow G ejected from the supersonic nozzleis curbed. A surface of the back plateon the supersonic gas flow G side may be a curved surface.

204 204 204 204 201 242 244 204 204 25 FIG. The knife edgeof this embodiment may be configured to be able to adjust an insertion length that is a length of the knife edgewhich is inserted into the supersonic gas flow G. Alternatively or additionally, the knife edgeof this embodiment may be configured to be able to adjust the insertion angle thereof. As an example of a configuration by which the knife edgeis realized, as illustrated in, the electron beam generation apparatusmay include a knife edge slide mechanismand an insertion angle adjusting mechanism. The insertion length is also referred to as an insertion depth. The insertion angle is also referred to as an inclination amount (inclination degree). The insertion angle is an angle between an extending direction (longitudinal direction) of the knife edgeand the X direction in a state in which the knife edgeis inserted into the supersonic gas flow G.

242 204 242 242 204 244 204 244 244 204 The knife edge slide mechanismis a mechanism that can change a length of the knife edgeinserted into the supersonic gas flow G. The knife edge slide mechanismis not particularly limited, and various known mechanisms can be employed. Examples of the knife edge slide mechanisminclude a mechanism that fixes, to a post, a rod having a tip to which a clamp holding the knife edgeis fixed, such that the rod is slidable in a longitudinal direction of the rod. The insertion angle adjusting mechanismis a mechanism that can change the insertion angle of the knife edge. The insertion angle adjusting mechanismis not particularly limited, and various known mechanisms can be employed. Examples of the insertion angle adjusting mechanisminclude a mechanism that fixes, to the post, a base end side of the rod having a tip to which the clamp holding the knife edgeis fixed, such that the rod can be rotatable about a rotation axis along the Y direction.

26 FIG. 1 2 3 4 5 is a graph illustrating a gas density distribution of the supersonic gas flow G in the X direction in a case where the insertion length is changed. In the drawing, a waveform Qindicates data in a case where the insertion length is set to a first value (for example, 0.5 mm). A waveform Qindicates data in a case where the insertion length is set to a second value (for example, 1.0 mm) larger than the first value. A waveform Qindicates data in a case where the insertion length is set to a third value (for example, 1.5 mm) larger than the second value. A waveform Qindicates data in a case where the insertion length is set to a fourth value (for example, 2.0 mm) larger than the third value. A waveform Qindicates data in a case where the insertion length is set to a fifth value (for example, 3.0 mm) larger than the fourth value.

26 FIG. 21 FIG. As illustrated in, it can be found that a change in the insertion length enables a magnitude and a position of a peak in the gas density distribution to be changed. This enables a length of the acceleration region AC (see) in which the gas density distribution is maintained within a certain range immediately after a peak thereof to be adjusted as desired. Since the generated electron beam E can be accelerated in the acceleration region AC, a change in the insertion length enables an acceleration energy of the electron beam E to be adjusted as desired.

27 27 a b FIGS.() and() 27 a FIG.() 27 b FIG.() 204 204 are graphs illustrating gas density distributions of the supersonic gas flow G in the X direction in a case where the insertion angle is changed.illustrates data in a case where the insertion angle is 0° (in a case where the extending direction of the knife edgeis the X direction).illustrates data in a case where the insertion angle is α (in a case where the extending direction of the knife edgeis inclined with respect to the X direction). Here, a is not particularly limited, and is, for example, an angle of 36° or smaller.

27 FIG. As illustrated in, it can be found that a change in the insertion angle enables the inclination of the shock wave I formed in the supersonic gas flow G to be changed, thus enabling the inclination of the shock front in the gas density distribution to be changed. For example, it can be found that, when the insertion angle is set to α, the inclination of the shock front in the gas density distribution can be increased as compared with the case where the insertion angle is 0°. It can be found that a width HO of the shock front in the X direction is, for example, 300 μm or smaller in the case where the insertion angle is 0°, whereas the width can be 140 μm or smaller in the case where the insertion angle is α. As a result, parameters (a charge amount, a probability of generation, and the like) of the electron beam E which is to be generated can be adjusted as desired.

28 FIG. 28 FIG. 28 FIG. 8 8 20 20 is a graph illustrating an experimental result of fluctuations in position of the shock wave I in the X direction in a fourth example and a fifth example. The fourth example corresponds to the electron beam generation apparatus according to the second embodiment including the mesh member. The fifth embodiment corresponds to an electron beam generation apparatus similar to that of the second embodiment except that the mesh memberis not provided. The horizontal axis inindicates fluctuations (umm) in position of the shock wave I in the X direction, and 0 is an average value (statistical average) in a case whereconsecutive shots of the pulsed laser light L are radiated. The vertical axis inrepresents a percentage (%) at which the fluctuations can occur in the case whereconsecutive shots of the pulsed laser light L are radiated.

28 FIG. 8 As illustrated in, in the fourth example, it can be found that, regarding fluctuations in position of the shock wave I in the X direction, 45% (nine shots) of the consecutive 20 shots are not moved from a position of 0 μm, and a moving range is also a range of −2 to 4 μm. According to these experimental results, as can be found from the comparison between the fourth example and the fifth example, the stability of the position of the shock front of the shock wave I depending on the presence or absence of the mesh member(high reproducibility of a position of a shock wave surface) can be confirmed.

29 FIG. 29 FIG. 28 FIG. 1 4 3 204 is a graph illustrating an experimental result of fluctuations in position of the shock wave I in the X direction in a sixth example and a seventh example. The horizontal axis and the vertical axis inare the same as the horizontal axis and the vertical axis in. The sixth example corresponds to the electron beam generation apparatusaccording to the first embodiment having the knife edgehaving at least the tip portion that is inclined toward the supersonic nozzlewith respect to the X direction. The seventh example corresponds to an electron beam generation apparatus similar to that of the first embodiment except that the knife edgeextending in the X direction (not inclined) is provided.

28 FIG. 4 204 4 As illustrated in, in the sixth example, it can be found that, regarding fluctuations in position of the shock wave I in the X direction, about 70% (14 shots) of the consecutive 20 shots are not moved from the position of 0 μm, and a moving range is also a range of −1 to 2 μm. In the seventh example, it can be found that, regarding fluctuations in position of the shock wave I in the X direction, about 40% (eight shots) of the consecutive 20 shots are not moved from the position of 0 μm, and a moving range is also a range of −2 to 4 μm. According to these experimental results, as can be found from the comparison between the sixth example and the seventh example, the stability of the position of the shock front of the shock wave I depending on each of the knife edgesandcan be confirmed. In addition, it has been confirmed that the position of the shock front of the shock wave I is particularly stable at the knife edge.

Although the embodiments have been described above, one aspect of the present invention is not limited to the above-described embodiments.

34 34 3 3 34 3 In the first embodiment and the second embodiment, the predetermined length of the flow straightening chamberis not particularly limited. The predetermined length of the flow straightening chambermay be a length larger than a size of an eddy that may be generated inside the supersonic nozzle. In the first embodiment and the second embodiment, the supersonic nozzleis configured to be dividable such that the flow straightening chamberis divided into three portions, but may be configured to be dividable such that the flow straightening chamber is divided into two or four or more portions. Alternatively, the supersonic nozzlemay not be configured to be dividable.

34 34 4 3 4 In the first embodiment and the second embodiment, the flow straightening chamberhas the constant flow channel cross-sectional area in the Z direction. However, the flow straightening chambermay include a portion having a flow channel cross-sectional area which is increased or decreased from one end to the other end thereof in the Z direction, or may include a portion having a flow channel cross-sectional area which is locally large or small. In the first embodiment and the second embodiment, the tip portion of the knife edgeis inclined toward the supersonic nozzlewith reference to the X direction, but the entire knife edgemay be inclined or may not be inclined.

8 34 In the second embodiment, the mesh memberis provided as the flow straightening member, but the flow straightening member is not limited to the mesh-shaped member, and may be another member as long as the member has a plurality of fine holes formed in the flowing direction of the flow straightening chamber. For example, the flow straightening member is not limited to the member having the net structure, and may be a plate in which a plurality of fine holes are formed.

8 63 64 8 8 63 64 8 62 63 In the second embodiment, one mesh memberis provided between the second middle memberand the bottom member, but the number and positions of the mesh membersare not particularly limited. For example, instead of or in addition to the mesh memberbetween the second middle memberand the bottom member, another mesh membermay be provided between the first middle memberand the second middle member.

5 In the first embodiment and the second embodiment, the first step and the second step may be executed simultaneously. In the embodiments, the pulsed laser light L is radiated along the X direction into the supersonic gas flow G from the one side in the X direction, but not limited to these embodiments. For example, the radiation unit may be configured to be able to adjust at least any one of a radiation direction, a radiation position, a position of the condensing point, and an optical axis (optical path) of the pulsed laser light L. For example, the pulsed laser light sourcemay be capable of changing the radiation position of the pulsed laser light L in the Z direction.

233 203 235 235 203 235 235 In the third embodiment described above, the gas flow channelof the supersonic nozzlehas two bent portions, but the number of bent portionsof the supersonic nozzlemay be one or three or more. In the third embodiment, the gas flow is bent from the Z direction toward the X direction by the bent portion, but not limited to the embodiment, and the bent portionmay bend the gas flow toward a direction intersecting the Z direction.

206 206 206 206 x x In the third embodiment, the through-holeof the back plateis provided along the X direction, but not limited to the embodiment, and the through-holemay penetrate the back platealong the propagation direction of the electron beam E. In the third embodiment, the first step and the second step may be executed simultaneously or in any order.

206 206 205 206 206 206 x x x, x In the third embodiment, the pulsed laser light L is radiated along the X direction into the supersonic gas flow G from the one side in the X direction, but not limited to the embodiment. For example, the radiation unit may be configured to be able to adjust at least any one of a radiation direction, a radiation position, a position of the condensing point LS, and an optical axis (optical path) of the pulsed laser light L. In this case, the through-holeof the back platemay have a size and/or a shape that can correspond to the corresponding adjustment. For example, the pulsed laser light sourcemay be capable of changing the radiation position of the pulsed laser light L in the Z direction, and in this case, the through-holemay be a long hole elongated in the Z direction. At this time, in order to reduce leakage of the supersonic gas flow G from the through-holea blocking portion (for example, a tape material or a plate material) capable of blocking a desired partial region in the through-holemay be provided.

203 206 203 206 206 232 235 203 The third embodiment described above includes both the supersonic nozzleand the back plate, but in the case where the supersonic nozzleis provided, the back platemay not be provided. In addition, in the third embodiment described above, in the case where the back plateis provided, and a supersonic nozzle including a gas channel through which a gas directly flows to the throatwithout the bent portionmay be provided instead of the supersonic nozzle.

Since the electron beam E that acts as a trigger for changing a prodrug into an active substance is generated, the embodiments described above can also be defined as the electron beam generation apparatus for a prodrug and the electron beam generation method for a prodrug. In this regard, the electron beam generation apparatus for a prodrug may further include at least any one of a patient table on which a patient is laid, a spin controller configured to control the spin of the generated electron beam E to be aligned in a specific direction, a magnetic field applying unit configured to apply an external magnetic field along the propagation direction to the generated electron beam E, an electric field applying unit configured to apply an external electric field such that polarities of the prodrugs are aligned, a beam monitor configured to measure an electron beam E transmitted through a prodrug, and a beam dump configured to absorb and stop the electron beam E transmitted through the prodrug.

In the embodiments described above, the prodrugs may include not only a general prodrug but also a multi-prodrug and a dual-prodrug. In addition, the electron beam E generated by the embodiments described above may be used not only as a trigger for changing a prodrug into an active substance but also for another drug delivery system. For example, the electron beam E generated according to the embodiments described above may be used to collapse a drug carrier and release a drug. That is, the embodiments described above can be defined as an electron beam generation apparatus for a drug carrier and an electron beam generation method for a drug carrier.

The radiation targets of the embodiments described above are not particularly limited. For example, the radiation target may be a medical agent that reacts to light (a photosensitizer and an optical immunotherapeutic agent). The electron beam generation apparatus according to an aspect of the present invention can be applied to various fields. Various materials and shapes can be applied to the configurations in the embodiments described above without being limited to the above-described materials and shapes. Some of the configurations in the embodiments described above can be omitted, as appropriate, without departing from the gist of one aspect of the present disclosure.

The embodiments described above may be used for treatment of a neurodegenerative disease such as Alzheimer's disease and brain diseases such as a brain tumor. In a case where the brain disease is targeted, an administered drug needs to transit a path from the bloodstream into the brain, but in this case, the drug has to pass through the blood-brain barrier separating the blood from the brain tissue. In general, it is known that a drug having high lipid solubility has high intracerebral transitivity. In the embodiments described above, when a prodrug having improved lipid solubility is produced by masking a substituent having low lipid solubility in the drug, and after the prodrug arrives in the brain, the prodrug is activated by radiating the electron beam E, it is expected that the intracerebral transitivity can be improved and the prodrug can act specifically on the brain.

To any one of the first embodiment, the second embodiment, the third embodiment, and the modification examples, at least some or all of the other characteristics of the embodiments and the modification examples may be applied. That is, the first embodiment may include, instead of or in addition to some of the configurations or the steps thereof, some or all of the configurations or the steps of at least any one of the second embodiment, the third embodiment, and the modification examples. The second embodiment may include, instead of or in addition to some of the configurations or the steps thereof, some or all of the configurations or the steps of at least any one of the first embodiment, the third embodiment, and the modification examples. The third embodiment may include, instead of or in addition to some of the configurations or the steps thereof, some or all of the configurations or the steps of at least any one of the first embodiment, the second embodiment, and the modification examples. The modification examples may include, instead of or in addition to some of the configurations or the steps thereof, some or all of the configurations or the steps of at least any one of the first embodiment, the second embodiment, and the third embodiment.

201 3 103 1 203 201 4 1 204 1 206 1 242 244 For example, the electron beam generation apparatusmay include the supersonic nozzleor the supersonic nozzle, or the electron beam generation apparatusmay include the supersonic nozzle. The electron beam generation apparatusmay include the knife edge, or the electron beam generation apparatusmay include the knife edge. The electron beam generation apparatusmay include the back plate. The electron beam generation apparatusmay include at least one of the knife edge slide mechanismand the insertion angle adjusting mechanism.

(1A) An electron beam generation device according to one aspect of the present invention is an electron beam generation apparatus configured to generate an electron beam by propagating pulsed laser light in a supersonic gas flow, the electron beam generation apparatus including a supersonic nozzle configured to generate the supersonic gas flow flowing along a first direction under a vacuum atmosphere; a knife edge configured to be inserted into the supersonic gas flow from one side in a second direction intersecting the first direction and form a shock wave in the supersonic gas flow, and a radiation unit configured to radiate the pulsed laser light into the supersonic gas flow and propagate the pulsed laser light to pass through the shock wave in the supersonic gas flow, in which the supersonic nozzle has a convergence portion having a downstream end forming a throat and an upstream end having a flow channel cross-sectional area larger than a cross-sectional area of the throat, and a flow straightening chamber configured to be smoothly connected to the upstream end of the convergence portion and extend by a predetermined length. The embodiments described above have the following characteristics.

(2A) In the electron beam generation apparatus according to (1A), the convergence portion and the flow straightening chamber may extend along the first direction, and the predetermined length may be 20 mm or longer. In this case, the flow straightening chamber of the supersonic nozzle enables, for example, the generation of a turbulent flow in the supersonic gas flow generated by the supersonic nozzle to be reliably curbed and enables the stability of the gas density distribution to be reliably enhanced. (3A) In the electron beam generation apparatus of the present invention according to (1A) or (2A), the supersonic nozzle may include a flow straightening member configured to be provided inside the flow straightening chamber and have a plurality of fine holes formed along a flowing direction of the flow straightening chamber. In this case, a flow rectification of the flow straightening member enables, for example, the generation of a turbulent flow in the supersonic gas flow generated by the supersonic nozzle to be further curbed and enables the stability of the gas density distribution to be further enhanced. (4A) In the electron beam generation apparatus according to (3A), the convergence portion and the flow straightening chamber may extend along the first direction, and the predetermined length may be 10 mm or longer. In this case, the flow straightening chamber of the supersonic nozzle enables, for example, the generation of a turbulent flow in the supersonic gas flow generated by the supersonic nozzle to be reliably curbed and enables the stability of the gas density distribution to be reliably enhanced. (5A) In the electron beam generation apparatus according to (3A) or (4A), the flow straightening member may be disposed inside the flow straightening chamber at a distance of 5 mm or longer from an upstream end or a downstream end of the flow straightening chamber. In this case, the flow rectification of the flow straightening member can be reliably exhibited. (6A) An electron beam generation method according to the present invention is an electron beam generation method for generating an electron beam by propagating pulsed laser light in a supersonic gas flow, the electron beam generation method including a first step of generating the supersonic gas flow flowing along a first direction under a vacuum atmosphere by a supersonic nozzle, a second step of inserting a knife edge into the supersonic gas flow from one side in a second direction intersecting the first direction and forming a shock wave in the supersonic gas flow, and a third step of radiating the pulsed laser light into the supersonic gas flow by a radiation unit, propagating the pulsed laser light to pass through the shock wave in the supersonic gas flow, and generating the electron beam, in which, in the second step, a plate member configured to be disposed by the other side of the supersonic nozzle in the second direction and project from the supersonic nozzle in the first direction beyond a condensing point of the pulsed laser light extends along a boundary plane of the supersonic gas flow, and in the third step, the generated electron beam passes through a through-hole formed in the plate member. In the electron beam generation apparatus according to the one aspect of the present invention, the supersonic gas flow is formed under the vacuum atmosphere by the supersonic nozzle, the knife edge is inserted into the formed supersonic gas flow, and the shock wave is formed in the supersonic gas flow. When the pulsed laser light is radiated and propagated in the supersonic gas flow, the pulsed laser light passes through the shock wave, thereby causing the electron beam having directionality to the other side in the second direction to be generated. Here, as a result of close studies, the present inventors have found that the stability of the electron beam is affected by the stability of a gas density distribution of the supersonic gas flow (hereinafter, also simply referred to as a “gas density distribution”). In this respect, in the one aspect of the present invention, since the supersonic nozzle has the flow straightening chamber, for example, generation of a turbulent flow (uncertainty in turbulent motion) in the supersonic gas flow generated by the supersonic nozzle can be curbed, and the stability of the gas density distribution can be enhanced. This enables the stability of the electron beam to be enhanced.

(7A) An electron beam generation method according to the present invention is an electron beam generation method for generating an electron beam by propagating pulsed laser light in a supersonic gas flow, the electron beam generation method including a first step of generating the supersonic gas flow flowing along a first direction under a vacuum atmosphere by a supersonic nozzle, a second step of inserting a knife edge into the supersonic gas flow from one side in a second direction intersecting the first direction and forming a shock wave in the supersonic gas flow, and a third step of radiating the pulsed laser light into the supersonic gas flow by a radiation unit, propagating the pulsed laser light to pass through the shock wave in the supersonic gas flow, and generating the electron beam, in which the first step includes a step of allowing a gas to flow from the outside to a throat that chokes a flow of the gas in the supersonic nozzle, and in the step of allowing the gas to flow to the throat, the flow of the gas in the supersonic nozzle is bent at least once toward a direction intersecting the first direction. In this electron beam generation method, the gas can be prevented from directly flowing from the outside of the supersonic nozzle to the throat, and the gas density distribution can be made uniform in the second direction. Also in this electron beam generation method, the plate member enables spreading of the supersonic gas flow ejected from the supersonic nozzle to the other side in the second direction to be curbed without interfering with the generated electron beam. This causes a strong shock wave to be stably formed in the supersonic gas flow, thereby enabling the stability of the gas density distribution to be enhanced and enabling the stability of the electron beam to be enhanced.

1 201 ,electron beam generation apparatus 3 103 203 ,,supersonic nozzle 4 204 ,knife edge 5 205 ,pulsed laser light source (radiation unit) 8 mesh member (flow straightening member) 31 throat 33 convergence portion 34 flow straightening chamber 206 back plate (plate member) 206 x through-hole 232 throat 233 gas flow channel 235 bent portion 235 A first bent portion 235 B second bent portion E electron beam G supersonic gas flow GB boundary plane I shock wave L pulsed laser light LS condensing point