Patentable/Patents/US-8540664
US-8540664

Probablistic pharmacokinetic and pharmacodynamic modeling

PublishedSeptember 24, 2013
Assigneenot available in USPTO data we have
Inventorsnot available in USPTO data we have
Technical Abstract

The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.

Patent Claims
11 claims

Legal claims defining the scope of protection. Each claim is shown in both the original legal language and a plain English translation.

Claim 2

Original Legal Text

2. The system of claim 1 , wherein the therapeutic and wellness data includes ingestible event marker data received from the ingestible event marker integrated with the substance, the ingestible event marker providing a signal when the substance is ingested.

Plain English Translation

The system for providing a response to a substance dose, comprising a processor and memory to determine a response based on received therapeutic and wellness data, also includes an ingestible event marker integrated with the substance. This marker sends a signal when the substance is ingested, and this signal data is part of the therapeutic and wellness data used by the system to determine the response. The ingestible event marker data provides precise timing information about when the substance was taken.

Claim 3

Original Legal Text

3. The system of claim 1 , wherein the therapeutic and wellness data includes data representative of physiological aspects associated with the ingestion of the ingestible event marker and the substance.

Plain English Translation

The system for providing a response to a substance dose, comprising a processor and memory to determine a response based on received therapeutic and wellness data, includes data representative of physiological aspects associated with the ingestion of an ingestible event marker and the substance. The therapeutic and wellness data therefore tracks the body's reaction (physiological aspects) to the substance being ingested, supplementing the ingestible event marker's timing data with details on how the body is processing the substance.

Claim 4

Original Legal Text

4. The system of claim 1 , wherein the therapeutic and wellness data includes one or more of the following: an ingestion time; an identification of the substance; an expiration date of the substance; a dosage amount for the substance; one or more physiological parameters associated with the reaction to at least one dose of the substance; a dosage of an intravenous substance; a heart rate; a blood pressure measurement; an optical measurement; a body temperature; a weight; an amount of an inhalant; an inhalation time; an identity of an inhaled substance; a galvanic skin response; an insertion time; and a drinking time.

Plain English Translation

The system for providing a response to a substance dose, comprising a processor and memory to determine a response based on received therapeutic and wellness data, collects various therapeutic and wellness data points. This data can include one or more of: ingestion time, substance identification, substance expiration date, substance dosage, physiological parameters related to the substance's reaction, intravenous substance dosage, heart rate, blood pressure, optical measurement, body temperature, weight, inhalant amount, inhalation time, inhaled substance identity, galvanic skin response, insertion time, and drinking time. This comprehensive dataset is used to determine the response to the substance.

Claim 5

Original Legal Text

5. The system of claim 1 , wherein the response determinator determines the response as a function of the therapeutic and wellness data.

Plain English Translation

The system for providing a response to a substance dose, comprising a processor and memory to determine a response based on received therapeutic and wellness data, calculates the response as a function of the collected therapeutic and wellness data. The response is not a fixed value, but rather a calculated value that depends on the specific input data received, allowing the system to tailor its response to the individual's condition and the substance being administered.

Claim 6

Original Legal Text

6. The system of claim 1 further comprising: a therapy controller configured to control, based on the response, at least one of an amount the substance and a time of the substance is ingested.

Plain English Translation

The system for providing a response to a substance dose, comprising a processor and memory to determine a response based on received therapeutic and wellness data, further includes a therapy controller. This controller adjusts either the amount of the substance or the time the substance is ingested based on the determined response. It acts as an automated control mechanism, using the response as feedback to optimize substance administration.

Claim 8

Original Legal Text

8. The system of claim 7 , wherein the therapy controller uses a closed-loop to control at least one of the dose of the substance and the time of the dose of the substance.

Plain English Translation

The system including a processor and memory to determine a response based on received therapeutic and wellness data, and a therapy controller configured to control the amount and timing of substance ingestion, utilizes a closed-loop control system. This closed-loop dynamically adjusts at least one of the substance dose and the time of the substance dose based on continuous feedback, creating a self-regulating system for substance administration.

Claim 9

Original Legal Text

9. The system of claim 7 , wherein the therapy controller uses a closed-loop to vary an input to the response to generate an output of the response, the output corresponding to at least one of the dose of the substance and the time of the dose of the substance.

Plain English Translation

The system including a processor and memory to determine a response based on received therapeutic and wellness data, and a therapy controller configured to control the amount and timing of substance ingestion, employs a closed-loop control mechanism. This closed loop alters an input to the response calculation to produce a specific output of the response that drives adjustments to the dosage amount or timing of the substance administration, actively manipulating the system for the desired effect.

Claim 10

Original Legal Text

10. The system of claim 7 , wherein the ingestible event marker data are received from the ingestible event marker integrated with the substance, the ingestible event marker providing a signal when the substance is ingested.

Plain English Translation

The system including a processor and memory to determine a response based on received therapeutic and wellness data, and a therapy controller configured to control the amount and timing of substance ingestion, receives ingestible event marker data from a marker integrated with the substance. The ingestible event marker signals precisely when the substance is ingested, providing crucial timing information to the system.

Claim 11

Original Legal Text

11. The system of claim 7 , wherein the therapeutic and wellness data represents physiological aspects associated with the ingestion of the ingestible event marker and the substance.

Plain English Translation

The system including a processor and memory to determine a response based on received therapeutic and wellness data, and a therapy controller configured to control the amount and timing of substance ingestion, utilizes therapeutic and wellness data that represents the physiological effects of ingesting both the substance and an associated ingestible event marker. This data reflects the body's reaction to the substance, providing a basis for determining the appropriate response.

Claim 12

Original Legal Text

12. The system of claim 7 , wherein the response is determined based on the reaction of at least one of an individual patient, a population, and a subset of the population.

Plain English Translation

The system including a processor and memory to determine a response based on received therapeutic and wellness data, and a therapy controller configured to control the amount and timing of substance ingestion, determines the response based on the reaction of an individual patient, a population, or a subset of that population. This means the response model can be personalized or based on population-level trends, enabling tailored therapy or broad-based guidelines.

Claim 13

Original Legal Text

13. The system of claim 7 , wherein the response is determined as a function of the therapeutic and wellness data.

Plain English Translation

The system including a processor and memory to determine a response based on received therapeutic and wellness data, and a therapy controller configured to control the amount and timing of substance ingestion, determines the response as a function of the available therapeutic and wellness data. The response is a calculated value derived directly from the input data, allowing the system to adapt to changing conditions and individual variations in health and behavior.

Classification Codes (CPC)

Cooperative Patent Classification codes for this invention. Click any code to explore related patents in that topic.

Patent Metadata

Filing Date

March 24, 2010

Publication Date

September 24, 2013

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Probablistic pharmacokinetic and pharmacodynamic modeling