The present invention provides a method for evaluating (predicting, etc.) an individual difference (the tendency of every individual) in terms of drug sensitivity and disease vulnerability, comprising using a gene polymorphism of a cyclic AMP responsive element binding protein gene or the like. The method for evaluating drug sensitivity and the method for evaluating disease vulnerability according to the present invention comprise associating a gene polymorphism of a cyclic AMP responsive element binding protein gene or a haplotype constituted by the gene polymorphism with the drug sensitivity and disease vulnerability of an individual.
Legal claims defining the scope of protection, as filed with the USPTO.
1. A method for treating a human subject with fentanyl following surgery comprising: (a) obtaining from the human subject a nucleic acid sample; (b) detecting the nucleic acids in the nucleic acid sample to determine the genotype of the rs2952768 polymorphism; (c1) administering to the human subject having a C/C genotype at rs2952768 a higher amount of fentanyl, wherein the higher amount of fentanyl is in comparison to predetermined median reference value, or (c2) administering to the human subject having a T/C or T/T genotype at rs2952768 a lower amount of fentanyl, wherein the lower amount of fentanyl is in comparison to predetermined median reference value.
2. The method according to claim 1 , wherein the nucleic acid sample is extracted from blood or oral mucosa of the human subject.
3. The method according to claim 1 , wherein the surgery is orthognathic surgery, and wherein the predetermined median reference value is 2.268 μg/kg.
4. The method according to claim 1 , wherein 4.80 to 5.08 μg/kg of fentanyl is administered to the human subject having a C/C genotype at rs2952768 after orthognathic surgery.
5. The method according to claim 1 , wherein 2.38 to 2.78 μg/kg of fentanyl is administered to the human subject having a T/T genotype at rs2952768 after orthognathic surgery.
6. The method according to claim 1 , wherein 2.38 to 2.99 μg/kg of fentanyl is administered to the human subject having a T/C genotype at rs2952768 after orthognathic surgery.
7. The method according to claim 1 , wherein the surgery is abdominal surgery, and wherein the predetermined median reference value is 2.453 μg/kg.
8. The method according to claim 1 , wherein 1.12 to 1.78 μg/kg of fentanyl is administered to the human subject having a C/C genotype at rs2952768 after abdominal surgery.
9. The method according to claim 1 , wherein 0.43 to 0.93 μg/kg of fentanyl is administered to the human subject having a T/T genotype at rs2952768 after abdominal surgery.
10. The method according to claim 1 , wherein 0.67 to 0.78 μg/kg of fentanyl is administered to the human subject having a T/C genotype at rs2952768 after abdominal surgery.
Cooperative Patent Classification codes for this invention. Click any code to explore related patents in that topic.
October 1, 2012
August 8, 2017
Browse 5M+ US patents with plain-English claim translations and AI-generated analysis.