A method of determining risk of diabetes is provided. In one embodiment, the method comprises: a) measuring the levels of a plurality of biomarkers in a blood samples obtained from a patient, wherein the plurality of biomarkers comprises at least five of the following biomarkers: glucose, adiponectin, CRP, IL2RA, ferritin, insulin and HbAIc; b) calculating a diabetes risk score for the patients using the levels and, optionally, patient age and/or gender. Results obtained from performing the assay on a reference population are similar or identical to those obtained using Formula I.
Legal claims defining the scope of protection, as filed with the USPTO.
2. The method of claim 1 , wherein said human reference population comprises at least 25 subjects.
3. The method of claim 1 , wherein the subjects of said human reference population are randomly chosen from a larger population of human subjects.
4. The method of claim 1 , further comprising: initiating a therapeutic intervention or a treatment regimen to delay, reduce or prevent the human subject's conversion to a diabetes disease state is performed if the calculated diabetes risk score indicates a risk that the subject has a high risk of developing diabetes.
5. The method of claim 1 , further comprising: initiating a therapeutic intervention or a treatment regimen to delay, reduce or prevent the human subject's conversion to a diabetes disease state is performed if the calculated diabetes risk score indicates a risk that the subject has a moderate risk of developing diabetes.
7. The method of claim 6 , wherein said subject is categorized into one of said risk categories using at least the levels of glucose, adiponectin, CRP and HbA1c in the blood of said subject, and subject age.
8. The method of claim 6 , wherein said human reference population comprises at least 25 subjects.
9. The method of claim 6 , wherein the subjects of said human reference population are randomly chosen from a larger population of human subjects.
10. The method of claim 6 , further comprising: c) initiating a therapeutic intervention or a treatment regimen to delay, reduce or prevent the human subject's conversion to a diabetes disease state if the calculated diabetes risk score indicates a risk that the subject will develop diabetes.
11. The method of claim 6 , further comprising: c) initiating a therapeutic intervention or a treatment regimen to delay, reduce or prevent the human subject's conversion to a diabetes disease state if the calculated diabetes risk score indicates a high risk or moderate risk that the subject will develop diabetes.
Cooperative Patent Classification codes for this invention. Click any code to explore related patents in that topic.
October 28, 2010
August 22, 2017
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